Results 131 to 140 of about 2,456,901 (316)

Second-generation lectin microarray for high throughput glycan profiling of therapeutic antibodies

AAPS Open
N-linked glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs), influencing efficacy, safety, and pharmacokinetics.
Kayla Hess, Helena Yun, Shen Luo, Uriel Ortega-Rodriguez, Grace Henry Lunde, Sarah Rogstad, Lai-Xi Wang, Baolin Zhang   +7 more
doaj   +1 more source

NMR-based structural integrity analysis of therapeutic monoclonal antibodies: a comparative study of Humira and its biosimilars

mAbs
The analytical comparability of biologic products and their biosimilars, including higher-order structure (HOS) assessment, ensures product quality and is required for regulatory approval.
Donna Baldisseri, Shen Luo, Christelle Anne F. Ancajas, Uriel Ortega-Rodriguez, Christian Fischer, Guozhang Zou, Jianghong Gu, David Keire, Martial Piotto, Baolin Zhang   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Effects of Carnosine Addition in Low-Fishmeal Feed on the Growth Performance, Muscle Antioxidant Capacity and Flesh Quality of Orange-Spotted Grouper (Epinephelus coioides)

Fishes
Carnosine is a natural dipeptide made up of L-histidine and β-alanine which is rich in muscle tissues and has multiple physiological functions. The current research aimed to investigate the effects of varied carnosine concentrations in low-fishmeal feed ...
Dong Li, Weijun Chen, Yanxia Yin, Lulu Yang, Mingfan Chen, Yunzhang Sun, Jidan Ye   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The evaluation and meta-evaluation design of the Presidio di Qualita di Ateneo (PARQ)

, 2012
The purpose of this paper is to describe the process of quality analysis made at the time of institution of the Presidio di Ateneo per la Qualità (PARQ), a structure for the internal quality control (required by Italian law), established at the ...
NUZZACI, Antonella
core  

Responding to Emergent Challenges and Opportunities

, 2019
This evaluation seeks to inform the World Bank’s efforts to support client countries to deliver sustainable irrigation and drainage services and achieve development impacts. The results of this evaluation can help
Independent Evaluation Group
core   +1 more source

Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology
Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases.
Haifan Liu, Xingyue Jin, Suyi Liu, Xinyue Liu, Xiao Pei, Kunhui Sun, Meifang Li, Ping Wang, Yanxu Chang, Tiejie Wang, Bing Wang, Xie-an Yu   +11 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Process improvement ensures high-quality disability benefit evaluation

, 2018
Blog post to Commonwealth Medicine's website - View blog post onlineOngoing quality management and review of disability benefit evaluation processes and procedures is critical for state and municipal retirement system administrators.
Simpson, Jody
core   +1 more source