Results 101 to 110 of about 6,659,971 (307)

Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis

Lipids in Health and Disease
Background Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain uncertain. Methods A rat model of NASH
Xiu-lian Lin, Ya-ling Zeng, Jie Ning, Zhe Cao, Lan-lan Bu, Wen-Jing Liao, Zhi-min Zhang, Tan-jun Zhao, Rong-geng Fu, Xue-Feng Yang, Yong-zhen Gong, Li-Mei Lin, De-liang Cao, Cai-ping Zhang, Duan-fang Liao, Ya-Mei Li, Jian-Guo Zeng   +16 more
doaj   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

A controlled vocabulary and taxonomy for the submission of quality attributes for therapeutic proteins

AAPS Open
Structured product quality data offer tremendous promise to revolutionize the submission of drug applications. However, the quality attributes for biological products do not have a systematic naming taxonomy, and consequently this limit poses a critical ...
Joel T. Welch, Steven Kozlowski, Bazarragchaa Damdinsuren, Brian A. Roelofs   +3 more
doaj   +1 more source

Consultation on changes to the academic infrastructure [PDF]

, 2010
"Th[e consultation] document sets out the proposals of the Quality Assurance Agency for Higher Education (QAA) for restructuring the Academic Infrastructure to address the findings of an evaluation completed in summer 2010. Overall, the results of the

core  

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

NMR-based structural integrity analysis of therapeutic monoclonal antibodies: a comparative study of Humira and its biosimilars

mAbs
The analytical comparability of biologic products and their biosimilars, including higher-order structure (HOS) assessment, ensures product quality and is required for regulatory approval.
Donna Baldisseri, Shen Luo, Christelle Anne F. Ancajas, Uriel Ortega-Rodriguez, Christian Fischer, Guozhang Zou, Jianghong Gu, David Keire, Martial Piotto, Baolin Zhang   +9 more
doaj   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections

AAPS Open
Freeze-drying has been a workhorse for the pharmaceutical industry to enable long-term storage and long-distance transport of drug products that are unstable in liquid or frozen form.
Steve Y. Rhieu, Maxwell Korang-Yeboah, David D. Anderson, John Arigo, Thomas O’Connor, Rakhi Shah   +5 more
doaj   +1 more source

Effects of Carnosine Addition in Low-Fishmeal Feed on the Growth Performance, Muscle Antioxidant Capacity and Flesh Quality of Orange-Spotted Grouper (Epinephelus coioides)

Fishes
Carnosine is a natural dipeptide made up of L-histidine and β-alanine which is rich in muscle tissues and has multiple physiological functions. The current research aimed to investigate the effects of varied carnosine concentrations in low-fishmeal feed ...
Dong Li, Weijun Chen, Yanxia Yin, Lulu Yang, Mingfan Chen, Yunzhang Sun, Jidan Ye   +6 more
doaj   +1 more source

DNN adaptation by automatic quality estimation of ASR hypotheses

, 2016
In this paper we propose to exploit the automatic Quality Estimation (QE) of ASR hypotheses to perform the unsupervised adaptation of a deep neural network modeling acoustic probabilities.
Falavigna, Daniele, Jalalvand, Shahab, Matassoni, Marco, Negri, Matteo, Turchi, Marco   +4 more
core   +1 more source