Results 81 to 90 of about 7,493,012 (309)

High-throughput, quantitative analyses of genetic interactions in E. coli. [PDF]

, 2008
Large-scale genetic interaction studies provide the basis for defining gene function and pathway architecture. Recent advances in the ability to generate double mutants en masse in Saccharomyces cerevisiae have dramatically accelerated the acquisition of
A Roguev, AB Byrne, AE Rizzitello, AH Tong, AH Tong, Athanasios Typas, Barry L Wanner, Bentley Lim, BJ Bachmann, BJ Breitkreutz, BR Bochner, C Boone, C Onufryk, Carol A Gross, CS Chen, Deborah A Siegele, E Cascales, E Cascales, ES Charlson, G Butland, Hannes Braberg, Hirotada Mori, HJ Nielsen, HJ Nielsen, HS Girgis, J Pogliano, J Qu, JC Bardwell, JG Sklar, Jonathan S Weissman, K Ara, KB Low, LI Leichert, LM Parsons, M Ito, M Schuldiner, MA Gerding, Michael Shales, Natsuko Yamamoto, Nevan J Krogan, P Mazurkiewicz, PE Rouviere, PN Danese, Rikiya Takeuchi, Robert J Nichols, Sean R Collins, SR Collins, SR Collins, T Baba, T Inoue, V Francois, WP Hoekstra, X Pan   +52 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Foraging environment determines the genetic architecture and evolutionary potential of trophic morphology in cichlid fishes [PDF]

, 2016
Phenotypic plasticity allows organisms to change their phenotype in response to shifts in the environment. While a central topic in current discussions of evolutionary potential, a comprehensive understanding of the genetic underpinnings of plasticity is
Albertson, R. Craig, Campbell, Calum, Concannon, Moira, Ea, Ilene, Groveas, Kiran, Navon, Dina, Parsons, Kevin J., Wang, Jason   +7 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Combined genetic and genomic approaches to characterize a durable Hevea resistance to South American leaf blight : S01T07 [PDF]

, 2013
The South American Leaf Blight (SALB), due to the Ascomycota Microcyclus ulei, threatens the world production of natural rubber, based on the cultivation of nearly only one species: the tropical tree Hevea brasiliensis.
Berger, Angélique, Doare, Fabien, Déon, Marine, Garcia, Dominique, Koop, Daniela Martins, Le Guen, Vincent, Pujade-Renaud, Valérie, Rippel, L.S., Rivallan, Ronan, Seguin, Marc   +9 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Assessment of genetic diversity in cowpea (Vigna unguiculata) [PDF]

Electronic Journal of Plant Breeding, 2010
Sixty six genotypes of cowpea (Vigna unguiculata (L.) Walp) were investigated to understand the extent of genetic diversitythrough twelve quantitative traits.
R.M.Nagalakshmi, R. Usha Kumari and M. B. Boranayaka
doaj  

Genetic diversity and selective breeding of red common carps in China [PDF]

, 2001
China has a very rich genetic diversity in common carp (Cyprinus carpio) and the red common carp plays an important role in Chinese aquaculture and genetic studies.
Li, S.F., Wang, C.H.
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Selection, inheritance, and the evolution of parent-offspring interactions

, 2004
Very few studies have examined parent-offspring interactions from a quantitative genetic perspective. We used a cross-fostering design and measured genetic correlations and components of social selection arising from two parental and two offspring ...
Lock, Judith E., Moore, Allen J., Smiseth, Per T.   +2 more
core   +1 more source