Results 41 to 50 of about 27,786,773 (306)
Pharmaceutics, 2021 Clofazimine (CFZ) is a poorly soluble, weakly basic, small molecule antibiotic clinically used to treat leprosy and is now in clinical trials as a treatment for multidrug resistant tuberculosis and COVID-19.
Steven Dunne +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quantitative X-Ray Diffraction Analysis of Zn-Al Based Alloys [PDF]
Archives of Metallurgy and Materials, 2020 The paper describes modification to Fm3–m (space group no. 225) lattice of aluminium based α-solid solution observed in Zn-Al alloys required to properly correlate quantitative data from X-ray diffraction analysis with results obtained from quantitative ...
P. Gogola +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Second order phase field asymptotics for multi-component systems [PDF]
, 2006 An asymptotic analysis of a phase field model for solidification in multicomponent alloy systems is presented. In the limit of vanishing interface thickness the related sharp interface model is approximated to second order by taking a non-constant ...
Stinner, Björn, Garcke, Harald
core +1 more source
Preliminary Assessment of Quantitative Phase Analysis from Focal Construct Tomography
NDT - Journal of Non-Destructive TestingNew methods for real-time materials phase identification based upon focal construct tomography (FCT) have been examined. Such quantitative assessment has significant potential in sectors where in-line analysis is required, including screening within ...
Varsha Samuel +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Phase transitions in single neurons and neural populations: Critical slowing, anesthesia, and sleep cycles [PDF]
, 2010 The firing of an action potential by a biological neuron represents a dramatic transition from small-scale linear stochastics (subthreshold voltage fluctuations) to gross-scale nonlinear dynamics (birth of a 1-ms voltage spike). In populations of neurons
Steyn-Ross, Moira L. +3 more
core +1 more source
Plant Communications, 2020 One of the hottest topics in plant hormone biology is the crosstalk mechanisms, whereby multiple classes of phytohormones interplay with each other through signaling networks.
Peiyong Xin +5 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source