Results 71 to 80 of about 857,162 (283)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation [PDF]

, 2018
We propose and experimentally demonstrate a method of polarization-sensitive quantitative phase imaging using two photodetectors and a digital micromirror device.
Lee, KyeoReh, Park, YongKeun, Shin, Seungwoo, So, Peter T. C., Yaqoob, Zahid   +4 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

On quantitativeness of diffraction-limited quantitative phase imaging

APL Photonics
Quantitative phase imaging (QPI) has advanced by accurately quantifying phase shifts caused by weakly absorbing biological and artificial structures. Despite extensive research, the diffraction limits of QPI have not been established and examined. Hence,
Zdeněk Bouchal, Petr Bouchal, Tereza Chmelíková, Jaromír Fiurášek   +3 more
doaj   +1 more source

Qualitative comparison of several phase correction algorithms in single-image in-line X-ray phase contrast tomography [PDF]

, 2013
In recent years, phase contrast has gained importance in the field of X-ray imaging and more particular in high-resolution X-ray computed tomography or micro-CT.
Boone, Matthieu, Dierick, Manuel, Luengo, Cris, Van Hoorebeke, Luc, Wernersson, Erik LG   +4 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Locality estimates for Fresnel-wave-propagation and stability of X-ray phase contrast imaging with finite detectors

, 2018
Coherent wave-propagation in the near-field Fresnel-regime is the underlying contrast-mechanism to (propagation-based) X-ray phase contrast imaging (XPCI), an emerging lensless technique that enables 2D- and 3D-imaging of biological soft tissues and ...
Maretzke, Simon
core   +1 more source

Quantitative imaging of the complexity in liquid bubbles' evolution reveals the dynamics of film retraction [PDF]

, 2018
The dynamics and stability of thin liquid films have fascinated scientists over many decades. Thin film flows are central to numerous areas of engineering, geophysics, and biophysics and occur over a wide range of length, velocity, and liquid properties ...
Di Maio, Ernesto, Ferraro, Pietro, Ferraro, Vincenzo, Maffettone, Pier Luca, Mandracchia, Biagio, Villone, Massimiliano Maria, Wang, Zhe   +6 more
core   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Volumetric Refractive Index Measurement and Quantitative Density Analysis of Mouse Brain Tissue with Sub‐Micrometer Spatial Resolution

Advanced Photonics Research, 2023
High‐resolution structural imaging of brain tissue is important for neuroscience research. However, conventional approaches have several limitations, such as the need for exogenous staining, limited accessibility to volumetric information, and ...
Ariel J. Lee, Herve Hugonnet, Young Seo Kim, Joon-Goon Kim, Moosung Lee, Taeyun Ku, YongKeun Park   +6 more
doaj   +1 more source