Results 71 to 80 of about 181,158 (299)

Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations

Brain : a journal of neurology
Post-mortem studies have shown that patients dying from severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection frequently have pathological changes in their CNS, particularly in the brainstem.
C. Rua, B. Raman, Christopher T. Rodgers, V. Newcombe, A. Manktelow, D. Chatfield, Stephen J. Sawcer, J. Outtrim, V. Lupson, E. Stamatakis, G. Williams, W. T. Clarke, L. Qiu, M. Ezra, R. McDonald, S. Clare, M. Cassar, Stefan Neubauer, K. Ersche, Edward T. Bullmore, D. Menon, K. Pattinson, J. B. Rowe   +22 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

MRI Quantification of Liver Fibrosis Using Diamagnetic Susceptibility: An Ex Vivo Validation Study

Tomography
Background/Objectives: Liver fibrosis, if left untreated, can lead to cirrhosis and cancer. The current standard liver biopsy for fibrosis staging is invasive and prone to risks of complication.
Chao Li, Jinwei Zhang, Alexey V. Dimov, Anne K. Koehne de González, Martin R. Prince, Jiahao Li, Dominick Romano, Pascal Spincemaille, Thanh D. Nguyen, Gary M. Brittenham, Yi Wang   +10 more
doaj   +1 more source

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Frontiers in Neuroscience
Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration.
Sadegh Ghaderi, Sana Mohammadi, Nahid Jashire Nezhad, Shaghayegh Karami, Fatemeh Sayehmiri   +4 more
semanticscholar   +1 more source

Multi-centre and multi-vendor reproducibility of a standardized protocol for quantitative susceptibility Mapping of the human brain at 3T.

Physica medica (Testo stampato), 2022
Quantitative Susceptibility Mapping (QSM) is an MRI-based technique allowing the non-invasive quantification of iron content and myelination in the brain.
M. Lancione, P. Bosco, M. Costagli, A. Nigri, D. Aquino, I. Carne, S. Ferraro, G. Giulietti, A. Napolitano, Fulvia Palesi, Luigi Pavone, A. Pirastru, G. Savini, F. Tagliavini, M. Bruzzone, C. G. Gandini Wheeler-Kingshott, M. Tosetti, L. Biagi   +17 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization

Scientific Reports, 2021
Quantitative susceptibility mapping (QSM) is a novel processing method for gradient-echo magnetic resonance imaging (MRI). Higher magnetic susceptibility in cortical veins have been observed on susceptibility maps in the ischemic hemisphere of stroke ...
Jasmin Probst, Marco Rohner, Malin Zahn, Marco Piccirelli, Athina Pangalu, Andreas Luft, Andreas Deistung, Jan Klohs, Susanne Wegener   +8 more
doaj   +1 more source

Quantitative susceptibility mapping for susceptibility source separation with adaptive relaxometric constant estimation (QSM-ARCS) from solely gradient-echo data

NeuroImage
To separate the contributions of paramagnetic and diamagnetic sources within a voxel, a magnetic susceptibility source separation method based solely on gradient-echo data has been developed. To measure the opposing susceptibility sources more accurately,
H. Kan, Yuto Uchida, Shohei Kawaguchi, H. Kasai, A. Hiwatashi, Yoshino Ueki   +5 more
semanticscholar   +1 more source

Assessing Mild Cognitive Impairment in Parkinson’s Disease by Magnetic Resonance Quantitative Susceptibility Mapping Combined Voxel-Wise and Radiomic Analysis

European Neurology, 2022
Background: The relationship between iron accumulation in the central nervous system and cognitive decline in Parkinson’s disease (PD) has not been fully elucidated.
Yi Zhao, Hang Qu, Wei Wang, Jiangbing Liu, Yu Pan, Zheng Li, Gang Xu, Chunhong Hu   +7 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source