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Bayes factors for detection of Quantitative Trait Loci [PDF]

open access: yesGenetics Selection Evolution, 2001
A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel   +2 more
doaj   +14 more sources

Interval mapping of multiple quantitative trait loci. [PDF]

open access: bronzeGenetics, 1993
Abstract The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead of the ...
Rick Jansen
openalex   +7 more sources

Quantitative Trait Loci: A Meta-analysis [PDF]

open access: bronzeGenetics, 2000
Abstract This article presents a method to combine QTL results from different independent analyses. This method provides a modified Akaike criterion that can be used to decide how many QTL are actually represented by the QTL detected in different experiments. This criterion is computed to choose between models with one, two, three, etc.,
Bruno Goffinet, Sophie Gerber
openalex   +7 more sources

Investigation of Splicing Quantitative Trait Loci in [PDF]

open access: yesGenomics & Informatics, 2016
The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo   +3 more
doaj   +1 more source

On the Fourier transform of a quantitative trait: Implications for compressive sensing [PDF]

open access: yesJournal of Theoretical Biology, Vol. 540, Year 2022, Article ID 110985, ISSN 0022-5193, 2021
This paper explores the genotype-phenotype relationship. It outlines conditions under which the dependence of a quantitative trait on the genome might be predictable, based on measurement of a limited subset of genotypes. It uses the theory of real-valued Boolean functions in a systematic way to translate trait data into the Fourier domain.
arxiv   +1 more source

Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes

open access: yesBiology, 2022
Since Darwin, biologists have sought to understand the evolution and origins of phenotypic adaptations. The skull is particularly diverse due to intense natural selection on feeding biomechanics.
Leah DeLorenzo   +8 more
doaj   +1 more source

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

open access: yesCells, 2023
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella   +12 more
doaj   +1 more source

Heterotic quantitative trait loci analysis and genomic prediction of seedling biomass-related traits in maize triple testcross populations

open access: yesPlant Methods, 2021
Background Heterosis has been widely used in maize breeding. However, we know little about the heterotic quantitative trait loci and their roles in genomic prediction.
Tifu Zhang   +8 more
doaj   +1 more source

Mapping Splicing Quantitative Trait Loci in RNA-Seq

open access: yesCancer Informatics, 2014
Background One of the major mechanisms of generating mRNA diversity is alternative splicing, a regulated process that allows for the flexibility of producing functionally different proteins from the same genomic sequences.
Cheng Jia   +3 more
doaj   +2 more sources

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