Overcoming collaboration barriers in quantitative trait loci analysis [PDF]
Cell GenomicsIn this issue of Cell Genomics, Choi et al.1 report a novel approach, privateQTL, which leverages secure multiparty computation (MPC) to enable federated expression quantitative trait loci (eQTL) mapping across institutions without compromising data ...
Wen Zhang, Xiaohong Wu, Jing Gong
doaj +2 more sources
Genetic mapping of quantitative trait loci in crops
Crop Journal, 2017 Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists. Two complementary approaches for genetic mapping, linkage mapping and association mapping have led to successful dissection of complex traits in many crop ...
Yang Xu +3 more
doaj +2 more sources
Powerful one-dimensional scan to detect heterotic quantitative trait loci [PDF]
Nature CommunicationsTo meet the growing global demand for food, increasing yields through heterosis in agriculture is crucial. A deep understanding of the genetic basis of heterosis has led to the development of a quantitative genetic framework that incorporates both ...
Guoliang Li +4 more
doaj +2 more sources
MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients [PDF]
Frontiers in Molecular NeuroscienceIntroductionMetabolic syndrome (MetS) and Parkinson’s disease (PD) share common pathophysiological and molecular impairments related to high PD incidence in MetS patients.
Guenson Chevalier +8 more
doaj +2 more sources
Secure and federated quantitative trait loci mapping with privateQTL [PDF]
Cell GenomicsSummary: Understanding the relationship between genotypes and phenotypes is crucial for advancing personalized medicine. Expression quantitative trait loci (eQTL) mapping plays a significant role by correlating genetic variants to gene expression levels.
Yoolim Annie Choi +4 more
doaj +2 more sources
A compendium of uniformly processed human gene expression and splicing quantitative trait loci
Nature Genetics, 2021 Many gene expression quantitative trait locus (eQTL) studies have published their summary statistics, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and co-localization.
N. Kerimov +16 more
semanticscholar +1 more source
Nature Genetics, 2021 Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3′
Lei Li +12 more
semanticscholar +1 more source
Investigation of Splicing Quantitative Trait Loci in [PDF]
Genomics & Informatics, 2016 The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo +3 more
doaj +1 more source
Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes
Biology, 2022 Since Darwin, biologists have sought to understand the evolution and origins of phenotypic adaptations. The skull is particularly diverse due to intense natural selection on feeding biomechanics.
Leah DeLorenzo +8 more
doaj +1 more source
Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas
Cells, 2023 In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella +12 more
doaj +1 more source