Results 101 to 110 of about 282,753 (347)

Genetic regulation of cholesterol absorption and plasma plant sterol levels

Journal of Lipid Research, 2003
The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP
Ephraim Sehayek
doaj  

The evolution of genetic architectures underlying quantitative traits

, 2013
In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across ...
Plotkin, Joshua B., Rajon, Etienne
core   +1 more source

A major genetic locus in Trypanosoma brucei is a determinant of host pathology [PDF]

, 2009
The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has ...
A Beckers, A Cooper, A Khan, A MacLeod, A MacLeod, A Martinelli, A Martinelli, Andy Tait, Annette MacLeod, B Namangala, C Su, C. Michael R. Turner, Christian Tschudi, CM Turner, CM Turner, CM Turner, CR Engwerda, DJ Weiss, DP Blake, E Lander, EM Fevre, F Iraqi, HA Noyes, J Masumu, J Naessens, JP Saeij, JP Saeij, K Hayton, K Taylor, KF Manly, L MacLean, L MacLean, LD Sibley, LD Sibley, Liam J. Morrison, Lindsay Sweeney, M Guilliams, M Guilliams, MP Barrett, MT Ferdig, MW Shirley, N Antoine-Moussiaux, O Hanotte, P Holzmuller, P Rohrbach, PR Gardiner, PR Gardiner, S Taylor, Sarah McLellan, SJ Kemp, T Bosschaerts, V Delespaux, VW Pentreath, X Su, Z Bengaly, Z Bengaly   +55 more
core   +3 more sources

Expression quantitative trait loci: present and future

Philosophical Transactions of the Royal Society B: Biological Sciences, 2013
The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative trait ...
Alexandra C. Nica, E. Dermitzakis
semanticscholar   +1 more source

Potential New Expression Biomarkers for Anorexia Nervosa

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta‐analysis of genome‐wide association studies on AN identified independent risk‐conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated.
Camille Verebi, Nicolas Lebrun, Justine Vily Petit, Odile Viltart, Philibert Duriez, Benjamin Saint‐Pierre, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
wiley   +1 more source

Optimal selection on two quantitative trait loci with linkage

Genetics Selection Evolution, 2002
A mathematical approach to optimize selection on multiple quantitative trait loci (QTL) and an estimate of residual polygenic effects was applied to selection on two linked or unlinked additive QTL.
Moreau Laurence, Chakraborty Reena, Dekkers Jack CM   +2 more
doaj   +1 more source

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source

Identification of major quantitative trait loci underlying floral pollination syndrome divergence in Penstemon

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
Distinct floral pollination syndromes have emerged multiple times during the diversification of flowering plants. For example, in western North America, a hummingbird pollination syndrome has evolved more than 100 times, generally from within insect ...
Carolyn A. Wessinger, Lena C. Hileman, M. Rausher   +2 more
semanticscholar   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Diversity and determinants of bitterness, astringency, and fat content in cultivated Nacional and native Amazonian cocoa accessions from Ecuador

The Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Cocoa (Theobroma cacao L.) is the only tree that can produce cocoa. Cocoa beans are highly sought after by chocolate makers to produce chocolate. Cocoa can be fine aromatic, characterized by floral and fruity notes, or it can be described as standard cocoa with a more pronounced cocoa aroma and bitterness.
Kelly Colonges, Edward Seguine, Alejandra Saltos, Fabrice Davrieux, Jérôme Minier, Juan‐Carlos Jimenez, Marie‐Christine Lahon, Darío Calderon, Cristian Subia, Ignacio Sotomayor, Fabián Fernández, Olivier Fouet, Bénédicte Rhoné, Xavier Argout, Marc Lebrun, Pierre Costet, Claire Lanaud, Renaud Boulanger, Rey Gastón Loor Solorzano   +18 more
wiley   +1 more source