Results 11 to 20 of about 90,018 (308)

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits. [PDF]

Nat Commun
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific
Wang L, Gao S, Chen S, Markus H, Wang G, Carrel L, Zhan X, Liu DJ, Jiang B.   +8 more
europepmc   +2 more sources

Overcoming collaboration barriers in quantitative trait loci analysis. [PDF]

Cell Genom
In this issue of Cell Genomics, Choi et al.1 report a novel approach, privateQTL, which leverages secure multiparty computation (MPC) to enable federated expression quantitative trait loci (eQTL) mapping across institutions without compromising data ...
Zhang W, Wu X, Gong J.
europepmc   +2 more sources

Powerful one-dimensional scan to detect heterotic quantitative trait loci. [PDF]

Nat Commun
To meet the growing global demand for food, increasing yields through heterosis in agriculture is crucial. A deep understanding of the genetic basis of heterosis has led to the development of a quantitative genetic framework that incorporates both ...
Li G, Schmidt RH, Zhao Y, Reif JC, Jiang Y.   +4 more
europepmc   +2 more sources

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients. [PDF]

Front Mol Neurosci
IntroductionMetabolic syndrome (MetS) and Parkinson’s disease (PD) share common pathophysiological and molecular impairments related to high PD incidence in MetS patients.
Chevalier G, Udovin L, Otero-Losada M, Bordet S, Perez-Lloret S, Capani F.   +5 more
europepmc   +2 more sources

Secure and federated quantitative trait loci mapping with privateQTL. [PDF]

Cell Genom
Summary: Understanding the relationship between genotypes and phenotypes is crucial for advancing personalized medicine. Expression quantitative trait loci (eQTL) mapping plays a significant role by correlating genetic variants to gene expression levels.
Choi YA, Kim Y, Miao P, Lappalainen T, Gürsoy G.   +4 more
europepmc   +2 more sources

A brief guide to analyzing expression quantitative trait loci. [PDF]

Mol Cells
: Molecular quantitative trait locus (molQTL) mapping has emerged as an important approach for elucidating the functional consequences of genetic variants and unraveling the causal mechanisms underlying diseases or complex traits. However, the variety of
Ko BS, Lee SB, Kim TK.
europepmc   +2 more sources

Identification of Quantitative Trait Loci and Candidate Genes Involved in Rice Seedling Growth Under Hypoxic Stress. [PDF]

Int J Mol Sci
Kim N, Jan R, Asif S, Asaf S, Khan Z, Kim KM.   +5 more
europepmc   +3 more sources

Investigation of Splicing Quantitative Trait Loci in [PDF]

Genomics & Informatics, 2016
The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo, Sungkyu Kyung, Seonggyun Han, Sangsoo Kim   +3 more
doaj   +1 more source

Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes

Biology, 2022
Since Darwin, biologists have sought to understand the evolution and origins of phenotypic adaptations. The skull is particularly diverse due to intense natural selection on feeding biomechanics.
Leah DeLorenzo, Victoria DeBrock, Aldo Carmona Baez, Patrick J. Ciccotto, Erin N. Peterson, Clare Stull, Natalie B. Roberts, Reade B. Roberts, Kara E. Powder   +8 more
doaj   +1 more source

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

Cells, 2023
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Géraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sébastien Jacques, Colin E. Murdoch, Francisco Miralles, Céline Méhats, Daniel Vaiman   +12 more
doaj   +1 more source