Results 51 to 60 of about 308,676 (247)

Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma

Scientific Reports
Lung squamous cell carcinoma (LUSC) is one of the most common types of non-small cell lung cancer with poor prognosis. Druggable genome-wide Mendelian randomization (MR) was conducted to discover LUSC-related targets using expression quantitative trait ...
Shizhao Cheng, Hao Zhang, Zhenliang Shi, Daqiang Sun   +3 more
doaj   +1 more source

Bayes factors for detection of Quantitative Trait Loci

Genetics Selection Evolution, 2001
A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel, García-Cortés Luis, Varona Luis   +2 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Genome-wide Identification of microRNA Expression Quantitative Trait Loci

Nature Communications, 2015
Identification of microRNA expression quantitative trait loci (miR-eQTL) can yield insights into regulatory mechanisms of microRNA transcription, and can help elucidate the role of microRNA as mediators of complex traits.
T. Huan, Jian Rong, Chunyu Liu, Xiaoling Zhang, K. Tanriverdi, R. Joehanes, Brian H. Chen, J. Murabito, C. Yao, P. Courchesne, P. Munson, C. O’Donnell, N. Cox, Andrew D. Johnson, M. Larson, D. Levy, J. Freedman   +16 more
semanticscholar   +1 more source

Rare variants contribute disproportionately to quantitative trait variation in yeast. [PDF]

, 2019
How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the contributions of common and rare variants to quantitative traits.
Bloom, Joshua S, Boocock, James, Day, Laura, Kruglyak, Leonid, Oates-Barker, Holly, Sadhu, Meru J, Treusch, Sebastian   +6 more
core   +1 more source

Quantitative trait loci markers derived from whole genome sequence data increases the reliability of genomic prediction.

Journal of Dairy Science, 2015
This study investigated the effect on the reliability of genomic prediction when a small number of significant variants from single marker analysis based on whole genome sequence data were added to the regular 54k single nucleotide polymorphism (SNP ...
R. Brøndum, G. Su, L. Janss, G. Sahana, B. Guldbrandtsen, D. Boichard, M. Lund   +6 more
semanticscholar   +1 more source

Population differences in transcript-regulator expression quantitative trait loci.

PLoS ONE, 2012
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a disease ...
Pierre R Bushel, Ray McGovern, Liwen Liu, Oliver Hofmann, Ahsan Huda, Jun Lu, Winston Hide, Xihong Lin   +7 more
doaj   +1 more source

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source

Development of a Next-Generation NIL Library in Arabidopsis Thaliana for Dissecting Complex Traits [PDF]

, 2013
The identification of the loci and specific alleles underlying variation in quantitative traits is an important goal for evolutionary biologists and breeders.
Bauerle, William L., Fletcher, Richard S., Juenger, Thomas E., McKay, John K., Meyer, Eli, Mullen, Jack L., Reuning, Gretchen, Sen, Saunak, Yoder, Seth   +8 more
core   +3 more sources

Identification and Mode of Inheritance of Quantitative Trait Loci for Secondary Metabolite Abundance in Tomato[OPEN]

The Plant Cell, 2015
Metabolite QTL for secondary metabolism in a Solanum pennelli introgression line population show different modes of inheritance and network properties linking the traits.
S. Alseekh, Takayuki Tohge, R. Wendenberg, F. Scossa, Nooshin Omranian, J. Li, Sabrina Kleessen, Patrick Giavalisco, T. Pleban, B. Mueller‐Roeber, D. Zamir, Z. Nikoloski, A. Fernie   +12 more
semanticscholar   +1 more source