Results 51 to 60 of about 282,753 (347)

Genome-wide Identification of microRNA Expression Quantitative Trait Loci

Nature Communications, 2015
Identification of microRNA expression quantitative trait loci (miR-eQTL) can yield insights into regulatory mechanisms of microRNA transcription, and can help elucidate the role of microRNA as mediators of complex traits.
T. Huan, Jian Rong, Chunyu Liu, Xiaoling Zhang, K. Tanriverdi, R. Joehanes, Brian H. Chen, J. Murabito, C. Yao, P. Courchesne, P. Munson, C. O’Donnell, N. Cox, Andrew D. Johnson, M. Larson, D. Levy, J. Freedman   +16 more
semanticscholar   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Quantitative trait loci markers derived from whole genome sequence data increases the reliability of genomic prediction.

Journal of Dairy Science, 2015
This study investigated the effect on the reliability of genomic prediction when a small number of significant variants from single marker analysis based on whole genome sequence data were added to the regular 54k single nucleotide polymorphism (SNP ...
R. Brøndum, G. Su, L. Janss, G. Sahana, B. Guldbrandtsen, D. Boichard, M. Lund   +6 more
semanticscholar   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Cowpea leaf width correlates with above ground biomass across diverse environments

Legume Science, Volume 4, Issue 4, December 2022., 2022
Abstract Cowpea (Vigna unguiculata [L.] Walp.) yields within the dry savannahs of Sub‐Saharan Africa are low. Given the contribution of cowpea to food security in this region, it is essential that high‐yielding varieties are developed to improve crop productivity in a sustainable manner.
Anthony Digrado, Emmanuel Gonzalez‐Escobar, Nicole Owston, Rhiannon Page, Saba Baba Mohammed, Muhammad Lawan Umar, Ousmane Boukar, Elizabeth A. Ainsworth, Elizabete Carmo‐Silva   +8 more
wiley   +1 more source

A Latent Variable Approach to Multivariate Quantitative Trait Loci [PDF]

, 2010
A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and ...
Bob O', Mikko J. Sillanpä, Outi Savolainen, Pä   +3 more
core   +1 more source

Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study [PDF]

, 2008
BackgroundMany studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait ...
Li, Ker-Chau, Sun, Wei, Yuan, Shinsheng
core   +3 more sources

Identification and Mode of Inheritance of Quantitative Trait Loci for Secondary Metabolite Abundance in Tomato[OPEN]

The Plant Cell, 2015
Metabolite QTL for secondary metabolism in a Solanum pennelli introgression line population show different modes of inheritance and network properties linking the traits.
S. Alseekh, Takayuki Tohge, R. Wendenberg, F. Scossa, Nooshin Omranian, J. Li, Sabrina Kleessen, Patrick Giavalisco, T. Pleban, B. Mueller‐Roeber, D. Zamir, Z. Nikoloski, A. Fernie   +12 more
semanticscholar   +1 more source

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Bean rust resistance in the Guatemalan climbing bean germplasm collection

Legume Science, Volume 4, Issue 4, December 2022., 2022
Abstract Common bean (Phaseolus vulgaris L.) is the main source of protein, fiber, and iron for Guatemala's poorest households. Bean rust (caused by Uromyces appendiculatus (Pers) Unger) can reduce seed yield up to 100%. There is limited information about U. appendiculatus virulence diversity in Guatemala, especially in the mid‐altitude highlands.
Luz de María A. Montejo Domínguez, Phillip E. McClean, James Steadman, Serena McCoy, Samuel Markell, Juan M. Osorno   +5 more
wiley   +1 more source