Results 201 to 210 of about 22,884 (241)

crRNA Truncation Minimizes <i>cis</i>-Cleavage for Universal One-Pot RPA-CRISPR-Cas12a Detection with Attomolar Sensitivity. [PDF]

JACS Au
Zhang W, Zhou Z, Feng X, Feng T, Liu X, Lin Q, Fan W, Liu C.   +7 more
europepmc   +1 more source

Evaluating Linker Architecture in RNA-Detecting Riboglow Probes and Effects on Fluorescence Turn-On. [PDF]

ACS Chem Biol
Shafik LK, Francis GM, Chitu G, Hanson J, Lis S, Cunningham K, Tatarian B, Van Dyke AR, Braselmann E.   +8 more
europepmc   +1 more source

Dynamic chiral quenching of europium and terbium excited states.

Phys Chem Chem Phys
Wen X, Black DJ, Fox MA, Pal R, Parker D.   +4 more
europepmc   +1 more source

Densely-functionalized bicyclic cyclopentanones by combined photoinduced 6-<i>endo-trig</i> Giese additions and mild aldol cyclizations.

Org Chem Front
Viñas-Lóbez J, Sellet N, Fabri B, Levitre G, de Aguirre A, Poblador-Bahamonde AI, Besnard C, Lacour J.   +7 more
europepmc   +1 more source

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A general configurational strategy to quencher-free aptasensors

Biosensors and Bioelectronics, 2021
The aptasensor, developed from the aptamer, has aroused wide concern in recent years owing to its high sensitivity and specificity. However, the quenching unit involved in the most of the aptasensors is indispensable to the fabrication of an aptasensor, which would undoubtedly increase the complexity of the device.
Lixuan Mu, Sen Liang, Guangwei She
exaly   +3 more sources

Quencher-free molecular aptamer beacons (QF-MABs) for detection of ATP

Bioorganic and Medicinal Chemistry Letters, 2015
We have constructed a simple and efficient system-based on quencher-free molecular aptamer beacons (QF-MABs)-for probing ATP. In the absence of ATP, the fluorescence of a pyrene fluorophore on the loop position (15 nucleotides from the 5' end) of the optimal QF-MAB was quenched by the neighboring nucleobases; in its presence, fluorescence was recovered,
Byeang Hyean Kim
exaly   +4 more sources

Quencher-free molecular beacon: Enhancement of the signal-to-background ratio with graphene oxide

Bioorganic and Medicinal Chemistry Letters, 2011
We report the highly improved version of quencher-free molecular beacon (QF-MB) system by using graphene oxide (GO) as an external quencher. This QF-MB/GO system provided a higher S/B ratio (31.0) relative to that (2.2) of the same system in the absence of GO, while retaining a high selectivity for fully matched over single-base-mismatched targets.
Jeong Wu Yi, Jaesung Park, N Jiten Singh   +2 more
exaly   +4 more sources

A quencher-free 2-aminopurine modified hairpin aptasensor for ultrasensitive detection of Ochratoxin A

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2020
A sensitive, efficient and quencher-free fluorescence aptasensor to detect Ochratoxin A (OTA) based on aptamer, 2-aminopurine (2AP) labeled Oligonucleotide sequence, as well as exonuclease I (Exo I) activity was developed. In which the aptamer specific to OTA was modified into a hairpin structure, and 8 bases at the 3' ends are exposed (H); also, 2AP ...
Yanhua He, Youwei Yu, Xiaoye Wen
exaly   +3 more sources

Quencher-free molecular beacons: a new strategy in fluorescence based nucleic acid analysis [PDF]

Chemical Society Reviews, 2008
Molecular beacons (MBs) have been used as viable fluorescent probes in nucleic acid analysis. Many researchers around the world continue to modify the MBs to suit their needs. As a result, a number of nucleic acid probing systems with close resemblance to the MBs are being reported from time to time.
Young Jun Seo, Byeang Hyean Kim
exaly   +4 more sources

Quencher-free hairpin probes for real-time detection of T4 polynucleotide kinase activity

Analytical Biochemistry, 2016
Traditional methods of assaying polynucleotide kinase (PNK) activity are discontinuous, time-consuming, and laborious. Here we report a new quencher-free approach to real-time monitoring of PNK activity using a 2-aminopurine probe. When the 2-aminopurine probe was 5'-phosphorylated by PNK, it could be efficiently degraded by lambda exonuclease to ...
Changbei Ma, Haisheng Liu, Han-Chun Chen   +2 more
exaly   +3 more sources