Results 51 to 60 of about 95,816 (273)

Network reinforcement driven drug repurposing for COVID-19 by exploiting disease-gene-drug associations [PDF]

arXiv, 2020
Currently, the number of patients with COVID-19 has significantly increased. Thus, there is an urgent need for developing treatments for COVID-19. Drug repurposing, which is the process of reusing already-approved drugs for new medical conditions, can be a good way to solve this problem quickly and broadly.
arxiv  

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

Journal of Functional Foods, 2018
Quercetin is hardly bioavailable and largely transformed to different metabolites. Although little is known about their biological activities, these metabolites are crucial for explanation of health benefits associated with quercetin dietary intake.
Marija Lesjak, Ivana Beara, Nataša Simin, Diandra Pintać, Tatjana Majkić, Kristina Bekvalac, Dejan Orčić, Neda Mimica-Dukić   +7 more
doaj  

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats

BMC Pharmacology and Toxicology, 2020
Background Quercetin, a pigment (flavonoid) found in many plants and foods, has good effects on protecting liver function but poor solubility and bioavailability in vivo.
Xiangyan Liu, Yang Zhang, Ling Liu, Yifeng Pan, Yu Hu, Pu Yang, Mingmei Liao   +6 more
doaj   +1 more source

Quercetin modulates ovarian autophagy–related molecules and stereological parameters in a rat model of PCOS

Asian Pacific Journal of Tropical Biomedicine, 2023
Objective: To examine the effect of quercetin on stereological parameters and autophagy-related genes in ovaries of polycystic ovary syndrome (PCOS) rats. Methods: Fifty female Sprague-Dawley rats were randomly divided into five groups: the control group,
Asma Neisy, Farhad Koohpeyma, Majid Jafari Khorchani, Fatemeh Karimi, Fatemeh Zal   +4 more
doaj   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of ...
Febriyenti, Peki Indra, Erizal Zaini, Friardi Ismed, Henny Lucida   +4 more
doaj  

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

Fabrication, Characterization, and In Vitro Testing of Quercetin–Copper(II) Complex

Nano Biomedicine and Engineering
Quercetin is a biologically active and widely used dietary flavonoid with robust antioxidant and chelating effects. However, due to its lesser solubility, it has poor bioavailability, which results in limited medicinal effects.
Sidra Sajid, Nazish Jahan, Zille Huma, Muhammad Ishaq Ali, Amir Zada, Aliya Ibrar, Ghulam Abbas Ashraf, Laila Noureen, Muhammad Ayaz, Samia Arain, Faiq Saeed   +10 more
doaj   +1 more source