Results 51 to 60 of about 3,014 (180)

Graph–Time IoT IDS: Requirement‐Aligned Impact Evaluation

Engineering Reports, Volume 8, Issue 7, July 2026.
A multi‐view intrusion detection framework (IMPACT‐MVG) combines temporal behavior modeling and graph‐based interaction analysis to detect IoT network attacks. Impact‐centric evaluation using the ICSec score shows that the approach reduces operational damage from intrusions while maintaining efficient, explainable, and privacy‐aware security monitoring.
Kumkum Dubey, Isha Batra, Abhishek Bajpai, Arun Malik, Mohammed Ali Alshara, Tariqullah Jan, Naveed Ahmad, Ruhul Amin Khalil   +7 more
wiley   +1 more source

PAD-Beads enrichment enhances detection of PrPSc using real-time quaking-induced conversion

BMC Research Notes, 2019
Objective Scrapie is a transmissible spongiform encephalopathy (TSE) that naturally occurs in sheep and goats. This fatal neurodegenerative disease results from misfolding of the normal cellular prion protein (PrPC) to a pathogenic prion protein form ...
Soyoun Hwang, Rohana P. Dassanayake, Eric M. Nicholson   +2 more
doaj   +1 more source

Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay. [PDF]

PLoS ONE, 2014
Real-time quaking-induced conversion (RT-QuIC), a highly specific and sensitive assay able to detect low levels of the disease-inducing isoform of the prion protein (PrP(d)) in brain tissue biopsies and cerebral spinal fluid, has great potential to ...
Keding Cheng, Angela Sloan, Kristen M Avery, Michael Coulthart, Michael Carpenter, J David Knox   +5 more
doaj   +1 more source

Cerebrospinal fluid α‐synuclein and Aβ42 link with default mode and salience networks connectivity in dementia with Lewy bodies

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include α‐synuclein, amyloid‐beta 42 (Aβ42), and tau protein aggregation. While cerebrospinal fluid (CSF) biomarkers provide in vivo insight into these pathologies,
Vincent Gabriel, Elena Chabran, Marion Sourty, Benjamin Cretin, Nathalie Philippi, Candice Muller, Pierre Anthony, Catherine Demuynck, Paulo Loureiro de Sousa, Anne Botzung, Léa Sanna, Olivier Bousiges, Frédéric Blanc   +12 more
wiley   +1 more source

kQUIC: A Kernel-Based Quick UDP Internet Connections (QUIC) Transport for IoT

IEEE Access
To address the shortcomings of TCP, the IETF has standardized QUIC, a new userspace transport protocol. Despite its benefits, the implementation of QUIC in the userspace introduces significant processing overhead, which makes it less suitable for IoT ...
Puneet Kumar, Behnam Dezfouli
doaj   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Use of bovine recombinant prion protein and real-time quaking-induced conversion to detect cattle transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-Type bovine spongiform encephalopathy. [PDF]

PLoS ONE, 2017
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc).
Soyoun Hwang, Justin J Greenlee, Eric M Nicholson   +2 more
doaj   +1 more source

Application value of real ⁃ time quaking ⁃ induced conversion technology in clinical diagnosis of Creutzfeldt⁃Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Creutzfeldt⁃Jakob disease (CJD) is a group of clinically rare neurodegenerative diseases caused by misfolding of prion proteins, and is the most common type of human prion diseases.
Dian HE
doaj   +1 more source

Website Fingerprinting in the Age of QUIC

Proceedings on Privacy Enhancing Technologies, 2021
Abstract With the meteoric rise of the QUIC protocol, the supremacy of TCP as the de facto transport protocol underlying web traffic will soon cease. HTTP/3, the next version of the HTTP protocol, will not support TCP. Current website-fingerprinting literature has ignored the introduction of this new protocol to all modern browsers.
Jean-Pierre Smith, Prateek Mittal, Adrian Perrig   +2 more
openaire   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source