Results 61 to 70 of about 3,014 (180)
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu +4 more
wiley +1 more source
PLoS ONEAccumulating evidence indicates that unpredictable signals in early life represent a unique form of adverse childhood experiences (ACEs) associated with disrupted neurodevelopmental trajectories in children and adolescents.
Sabrina R Liu +6 more
doaj +1 more source
Steganography in the QUIC Communication Protocol [PDF]
JUCS - Journal of Universal Computer ScienceNetwork steganography has existed for several decades and it uses network traffic and network protocols as carriers for embedding secret messages in a stealthy manner. Quick UDP Internet Connections (QUIC) is a novel secure and reliable transport layer network protocol that is encapsulated in the User Datagram Protocol (UDP) and utilizes the Transport ...
Aleksandar Velinov +4 more
openaire +2 more sources
Optimization of the Real-Time Quaking-Induced Conversion Assay for Prion Disease Diagnosis
Frontiers in Bioengineering and Biotechnology, 2020 The real-time quaking-induced conversion (RT-QuIC) assay is a highly reproducible and robust methodology exhibiting an excellent pre-mortem diagnostic accuracy for prion diseases.
Inga Zerr +11 more
doaj +1 more source
QUIC-Fuzz: An Effective Greybox Fuzzer For The QUIC Protocol
Network applications are routinely under attack. We consider the problem of developing an effective and efficient fuzzer for the recently ratified QUIC network protocol to uncover security vulnerabilities. QUIC offers a unified transport layer for low latency, reliable transport streams that is inherently secure, ultimately representing a complex ...
Kian Kai Ang, Damith C. Ranasinghe
openaire +2 more sources
α‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK2‐linked Parkinson's disease
Annals of Clinical and Translational Neurology, 2019 Background Leucine‐rich kinase 2 (LRRK2)‐linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy‐type ...
Alicia Garrido +5 more
doaj +1 more source
Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Satish K. Nemani +6 more
wiley +1 more source
Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation
Advanced Science, Volume 13, Issue 27, 13 May 2026.Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li +5 more
wiley +1 more source
PLoS ONE, 2019 Detection of misfolded prion protein, PrPTSE, in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (TSEs).
Nadine Kaelber +3 more
doaj +1 more source