Results 61 to 70 of about 387 (133)
Cancer Medicine, Volume 15, Issue 5, May 2026.ABSTRACT Both fruquintinib and TAS‐102 monotherapies are guideline‐recommended for third‐line treatment of metastatic colorectal cancer (mCRC). This study aimed to analyze the preliminary outcomes of fruquintinib combined with TAS‐102, with or without stereotactic body radiation therapy (SBRT), as a third‐ or later‐line therapy for mCRC.
Yi Wang +19 more
wiley +1 more source
Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018 Promising biologically active substances are derivatives of imidazole and quinazoline, which are part of the structure of known antifungal drugs and substances with anti-TB and antimicrobial activity.
O. A. Zavada +2 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 5, May 2026.In the syngeneic tumor mouse model, capecitabine inhibits TYMS by metabolizing to 5‐fluorouracil in vivo, which leads to the activation of intracellular NOX. The massive release of ROS leads to the accumulation of ferrous ions in mitochondria, and the imbalance of intracellular oxidative stress and the accumulation of ferrous ions cause ferroptosis of ...
Ruining Yang +13 more
wiley +1 more source
Discovery of cytotoxic indolo[1,2-c]quinazoline derivatives through scaffold-based design
Beilstein Journal of Organic ChemistryIndolo[1,2-c]quinazoline derivatives have emerged as promising chemotype in drug discovery due to their versatile biological activities, including antimicrobial and antiviral properties.
Daniil V. Khabarov +5 more
doaj +1 more source
MoleculesTrypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez +7 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2015 A series of functionalized benzimidazo[1,2-c]quinazoline derivatives was obtained in excellent yields under mild conditions through a CuI-catalyzed Ullmann N-arylation starting from easily available starting materials.
Xinlong Pang +3 more
doaj +1 more source
Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents
Saudi Pharmaceutical Journal, 2017 A series of ten novel chalcone incorporated quinazoline derivatives (11a-11j) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375).
Sapavat Madhavi +3 more
openaire +3 more sources
Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
Molecules, 2009 Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical ...
Martha Cecilia Meza +4 more
doaj +1 more source
Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives
Molecules, 2017 In an attempt to explore a new class of epidermal growth factor receptor (EGFR) inhibitors, novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth rearrangement reaction and characterized via IR, 1H-NMR, 13C-NMR, and HRMS. Methoxyl, methyl, halogen, and trifluoromethyl groups on stilbeneamino were detected.
Liuchang Wang +5 more
openaire +3 more sources
Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring
Антибиотики и ХимиотерапияThe aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova +4 more
doaj +1 more source