Results 61 to 70 of about 623,955 (160)

Synthesis and characterization of some new 4-heteroaryl quinazoline and fused triazolo quinazoline derivatives

, 2016
Treatment of chloroquinazoline (2) with primary amines (2-aminothiazoles and sulpha drugs) and secondary amines (morpholine, piperidine, and piperazine) furnished 4-substituted aminoquinazolines (3a,b and 4a,b), 4-aryl quinazolines (5a,b), and ...
El-Badry, Yaser Abdel-Moemen, El-Hashash, Mahr Abdel-Aziz, Nassar, Ekhlass   +2 more
core   +1 more source

Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease

Molecules
Quinazoline, a privileged scaffold in medicinal chemistry, offers promising potential in the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables the design of ...
Qais Abualassal, Zead Abudayeh, Ala’ Sirhan, Abdulrahman Mkia   +3 more
doaj   +1 more source

Preparation of skeletally diverse quinazoline-2,4(1H,3H)-diones using Na2SiO3/SnFe2O4 catalytic system through a four-component reaction

Main Group Metal Chemistry, 2020
Sodium silicate with the formula of Na2SiO3 was used for the four-component reaction of ketones, aldehydes and cyanoacetamide. The effect of SnFe2O4 nano-particles on the catalytic potential of Na2SiO3 was investigated.
Ayambekam Fazilat, Ghashang Majid
doaj   +1 more source

A Blood–Brain Barrier‐Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana, Nicoletta Collura, Andrea Gotti, Giulia De Leonardis, Greta Donati, Alice Maiocchi, Luciana Marinelli, Andrea Menegon, Pierfausto Seneci   +8 more
wiley   +1 more source

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

Biological Research, 2008
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors.
GLORIA D GALARCE, ROCÍO E FONCEA, ANA M EDWARDS, HERNÁN PESSOA-MAHANA, CARLOS D PESSOA-MAHANA, ROBERTO A EBENSPERGER   +5 more
doaj  

Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)

Molecules
Cancer is a complicated, multifaceted disease that can impact any organ in the body. Various chemotherapeutic agents have a low selectivity and are very toxic when used alone or in combination with others.
Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim, Sameh H. Abdelwahed   +4 more
doaj   +1 more source

Fragment‐Based Screening of Heterocyclic Electrophiles Identified Acrylamide Bioisoteres for Covalent KRasG12C Inhibitors

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka, Aaron Keeley, Péter Ábrányi‐Balogh, Zoltán Orgován, László Petri, Emma K. Grant, Chad Quinn, Soma Csanády, Ivan Randelovic, József Tóvári, Jacob Bush, György M. Keserű   +11 more
wiley   +1 more source

Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug

Journal of the Turkish Chemical Society, Section A: Chemistry
This study reports the synthesis of new hydralazine-based heterocyclic derivatives (S1–S8), including β-lactam, aza-β-lactam, and quinazoline-4-one derivatives.
Ruaa Dhedan, Aseel Hikmat, Noor Kadhem, Hind Sedeeq, Rana Ali, Sanaa Abdul Alsahib   +5 more
doaj   +1 more source

Access to Original Vinylic Chlorides in the Quinazoline Series via a Monoelectronic Transfer Reaction Approach

Molecules, 2010
A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive SRN1 / ERC1 radical strategy.
Martine Maillard-Boyer, Caroline Castera-Ducros, Pierre Verhaeghe, France Sifredi, Pascal Rathelot, Patrice Vanelle   +5 more
doaj   +1 more source

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source