Results 71 to 80 of about 387 (133)

NEW POTENTIAL ANTI-INFLAMMATORY QUINAZOLINE-2,4(1H,3H)-DIONE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences, 2001
A series of nucleophilic and condensation reactions were carried out to synthesize 1.3,4-triazolyimethoxyphenyl and 1,3.4-Oxadiazoly1methoxyphenyl derivatives of quinazoline-2,4(1H,3H)-dione as potential anti-inflammatory agents.
Samy Sakr
doaj   +1 more source

Quinazoline Derivatives as Targeted Chemotherapeutic Agents

Cureus
Most of the current chemotherapeutic medications are extremely toxic, exhibit little selectivity, and contribute to the emergence of treatment resistance. Consequently, the discovery of targeted chemotherapy drugs with high selectivity and low side effects is necessary for cancer treatment. The quinazoline system has a broad range and a long history of
openaire   +2 more sources

Prevention of Weight Regain After GLP1RA Cessation With Oral TIX100

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5339-5342, June 2026.
SeongHo Jo, Junqin Chen, Gu Jing, Guanlan Xu, Peng Li, Anath Shalev   +5 more
wiley   +1 more source

A comparative QSAR analysis and molecular docking studies of quinazoline derivatives as tyrosine kinase (EGFR) inhibitors: A rational approach to anticancer drug design

Journal of Saudi Chemical Society, 2011
In this paper, an attempt was made to develop a quantitative structure–activity relationship (2D and 3D QSAR) and molecular docking studies on a series of quinazoline derivatives acting as protein tyrosine kinases (EGFR) inhibitors. 2D QSAR was performed
Malleshappa N. Noolvi, Harun M. Patel
doaj   +1 more source

Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents

Chemistry Central Journal, 2017
Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc.
Danah S. Al-Shamary, Monirah A. Al-Alshaikh, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot, Syed Lal Badshah   +4 more
doaj   +1 more source

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences
In recent years, the use of quinazoline and its derivatives as structural scaffolds has shown significant promise in drug design. These compounds have shown significant biological efficacy in the treatment of a variety of diseases, including cancer ...
Mostafa Mansour, Samar Abbas, Asma AboulMagd, Hamdy Abdel-Rahman, Mohamed Osman   +4 more
doaj   +1 more source

Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones

Molecules, 2013
A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation
Weimin Mo, Nan Sun, Xinquan Hu, Ming Guo, Zhenlu Shen, Lili Sheng, Xiaochu Zhang, Baoxiang Hu   +7 more
doaj   +1 more source

Therapeutic Potential of Quinazoline Derivatives

International Journal of Pharmacy and Pharmaceutical Research, 2023
A. Tejasri, P. Maheshwari
openaire   +1 more source

2-Azidobenzaldehyde-Enabled Construction of Quinazoline Derivatives: A Review

International Journal of Molecular Sciences
Quinazoline is a privileged heterocyclic scaffold commonly found in numerous pharmaceuticals and bioactive natural products, known for its diverse biological activities. The pursuit of efficient and versatile synthetic methods to produce quinazoline derivatives remains a central focus for organic and medicinal chemists, owing to the therapeutic ...
Weiqi Qiu, Desheng Zhan, Xiaoming Ma, Xiaofeng Zhang   +3 more
openaire   +2 more sources

Use of quinazoline derivatives for neurodegenerative diseases

, 2009
Consejo Superior de Investigaciones Científicas (España)
Martínez Gil, Ana, Gil, Carmen, Pérez, Concepción, Pérez Castillo, Ana, Morales, María, Redondo, Miriam, Sanz-SanCristóbal, Marina   +6 more
openaire   +1 more source