Results 71 to 80 of about 623,955 (160)

Structure-Activity Relationship and Docking Study of Non-Quinazoline EGFR/VEGFR Dual Inhibitors. A Review [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The dual inhibitors of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) have been developed as a promising strategy for cancer therapy.
Fatemeh Yousefbeyk, Saeed Ghasemi
doaj   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, Volume 117, Issue 9, Page 2345-2356, September 2026.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation

, 2016
[ARCHIVES] Copyright Article from: Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (Fakultas Farmasi UNAIR-Surabaya)Background: Nowadays, a lot of new active substances as anticancer agents have been developed.
Widiyana, Anita P, Putra, Galih S, Muclashi, Luthfi A   +2 more
core  

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree BV, Anguraj Moulishankar, Viney Chawla, Pooja A. Chawla   +6 more
wiley   +1 more source

Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018
Promising biologically active substances are derivatives of imidazole and quinazoline, which are part of the structure of known antifungal drugs and substances with anti-TB and antimicrobial activity.
O. A. Zavada, O. V. Tkachenko, I. O. Zhuravel   +2 more
doaj   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, Volume 59, Issue 9, September 2026.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Setting of an import tolerance for fenazaquin in teas

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Gowan Crop Protection Limited submitted a request to the competent national authority in Germany to set an import tolerance for the active substance fenazaquin in teas imported from India.
European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Irene Castellan, Monica del Aguila, Lucien Ferreira, Renata Leuschner, Andrea Mioč, Marta Szot, Manuela Tiramani, Alessia Verani   +10 more
wiley   +1 more source

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents [PDF]

, 2016
A series of ten novel chalcone incorporated quinazoline derivatives (11a–11j) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375 ...
Raju, Rudraraju Ramesh, Rudraraju Ramesh Raju, Yazala, Jyothsna Pragathi, Reddymasu Sreenivasulu, Jyothsna Pragathi Yazala, Sapavat Madhavi, Sreenivasulu, Reddymasu, Madhavi, Sapavat   +7 more
core   +1 more source

Synthesis of pyrrolo[1,2-c]quinazoline derivatives

, 1992
Δ2-Pyrrolin-4-ones 12 and 13, prepared from 1-acyl-3-alkyl-1,3-dihydro-2H-indol-2-ones 1, via the corresponding 3-bromo-, 2 and 6, 3-azido, 7 and 8, and 3-iminophosphorane 9 and 10, were cyclized to the corresponding pyrrolo[1,2-c]quinazoline derivatives
A. Marchesini, Tullio Pilati, T. Pilati, E.M. Beccalli, Egle M. Beccalli, Alessandro Marchesini   +5 more
core   +1 more source