Results 1 to 10 of about 38,165 (238)

Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review

Frontiers in Neurology, 2019
Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from
Yu Jia, Yu Jia, Yicong Lin, Yicong Lin, Jing Li, Jing Li, Mingyu Li, Mingyu Li, Yifan Zhang, Yifan Zhang, Yue Hou, Yue Hou, Aihua Liu, Aihua Liu, Liping Zhang, Liping Li, Liping Li, Peng Xiang, Peng Xiang, Jing Ye, Jing Ye, Zhaoyang Huang, Zhaoyang Huang, Yuping Wang, Yuping Wang   +24 more
doaj   +2 more sources

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

PLoS ONE, 2017
AimsShort QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr)
Cunjin Luo, Kuanquan Wang, Henggui Zhang
doaj   +2 more sources

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

Frontiers in Physiology, 2017
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of drug
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez   +5 more
doaj   +2 more sources

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Frontiers in Physiology, 2017
The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatment ...
Dominic G. Whittaker, Haibo Ni, Alan P. Benson, Alan P. Benson, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang   +8 more
doaj   +2 more sources

Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function [PDF]

Iranian Journal of Medical Sciences
Background: Calcium enters human sperm through the “Cation Channel of Sperm” (CatSper), while potassium ions exit via the sperm potassium channel (KSper).
Ali Asghar Zarei, Sara Keshtgar, Masoud Haghani, Negar Firouzabadi, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +2 more sources

A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]

PLoS Genetics, 2014
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T Ferdig, Wilfred D Stein, Michael Lanzer   +8 more
doaj   +2 more sources

Quinidine for Brugada syndrome: Panacea or poison? [PDF]

HeartRhythm Case Reports, 2016
published_or_final_versio
Jo-Jo Hai, MBBS, Chun-Ka Wong, MBBS, Pak-Hei Chan, MBBS, Hung-Fat Tse, MD, PhD, Tak-Cheung Yung, MBBS, Chung-Wah Siu, MD   +5 more
doaj   +2 more sources

Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect

Neuropsychiatric Disease and Treatment, 2014
Kerri A Schoedel,1 Sarah A Morrow,2 Edward M Sellers3,4 1Altreos Research Partners, Inc., Toronto, 2Western University, London, 3DL Global Partners, Inc., Toronto, 4University of Toronto, Toronto, Ontario, Canada Abstract: Pseudobulbar affect (PBA) is ...
Schoedel KA, Morrow SA, Sellers EM
doaj   +2 more sources

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine.

Angewandte Chemie, 2021
Na v 1.5, the primary voltage-gated Na + (Na v ) channel in heart, is a major target for class I antiarrhythmic agents. Here we present the cryo-EM structure of full-length human Na v 1.5 bound to quinidine, a class Ia antiarrhythmic drug, at 3.3 Å ...
Zhangqiang Li, Xueqin Jin, Tong Wu, Gaoxingyu Huang, Kun Wu, J. Lei, Xiaojing Pan, N. Yan   +7 more
semanticscholar   +1 more source

Efficacy of Anti-seizure Medications, Quinidine, and Ketogenic Diet Therapy for KCNT1-Related Epilepsy and Genotype-Efficacy Correlation Analysis

Frontiers in Neurology, 2022
AimTo evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations.MethodsWe collected the data for KCNT1-related epilepsy cases from our ...
Zehong Lin, Zehong Lin, Zehong Lin, Tian Sang, Tian Sang, Tian Sang, Ying Yang, Ying Yang, Ying Yang, Yuan Wu, Yuan Wu, Yuan Wu, Yan Dong, Taoyun Ji, Taoyun Ji, Taoyun Ji, Yuehua Zhang, Yuehua Zhang, Yuehua Zhang, Ye Wu, Ye Wu, Ye Wu, Kai Gao, Kai Gao, Kai Gao, Kai Gao, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang   +30 more
doaj   +1 more source