Results 1 to 10 of about 4,652 (165)
SYNTHETIC SUBSTITUTES FOR QUINIDINE [PDF]
British Journal of Pharmacology and Chemotherapy, 1946 G. S. Dawes
openaire +9 more sources
Frontiers in Neurology, 2022 AimTo evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations.MethodsWe collected the data for KCNT1-related epilepsy cases from our ...
Zehong Lin +30 more
doaj +1 more source
Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report
Frontiers in Pediatrics, 2022 Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral ...
Yi Zhang, He Jiang, Xiao-mei Li
doaj +1 more source
A case report of pitfall of fever and altered mental status: cerebral malaria due to in an adult traveler returning from Congo [PDF]
Journal of Neurocritical Care, 2023 Background Cerebral malaria, caused by Plasmodium falciparum, can lead to severe neurological complications. It is more frequently observed in children than in adults.
Soo-Hyun Park +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Case introduction: In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic ...
M. C. Kravetz +6 more
doaj +1 more source
Annals of Noninvasive Electrocardiology, Volume 28, Issue 1, January 2023., 2023 Numerous T wave morphology biomarkers, which can supplement QTc assessment in long QT syndrome (LQTS), have been identified. Their diagnostic capabilities include differentiation of genotypes, identification of concealed LQTS, differentiating acquired LQTS from congenital LQTS; and determining multichannel versus hERG channel blockade.
Daniel T. Tardo +4 more
wiley +1 more source
Canine and feline P‐glycoprotein deficiency: What we know and where we need to go
Journal of Veterinary Pharmacology and Therapeutics, Volume 46, Issue 1, Page 1-16, January 2023., 2023 Abstract In 2001 the molecular genetic basis of so‐called “ivermectin sensitivity” in herding breed dogs was determined to be a P‐glycoprotein deficiency caused by a genetic variant of the MDR1 (ABCB1) gene often called “the MDR1 mutation.” We have learned a great deal about P‐glycoprotein's role in drug disposition since that discovery, namely that P ...
Katrina L. Mealey +2 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient ...
Mengying Huang +23 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source