Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics [PDF]
Frontiers in Veterinary ScienceIntroductionQuinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects.
Taisuke Kuroda +12 more
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Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma [PDF]
Clinical and Experimental OtorhinolaryngologyObjectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis.
Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh
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A Tale of Two Conditions: Pediatric Brugada Syndrome Unveiled-Navigating the Challenges of Coexisting Arrhythmia and Fever-Induced ECG Pattern. [PDF]
Ann Noninvasive ElectrocardiolFever often unmask Brugada syndrome (BrS) in children. Asymptomatic kids with fever‐induced type 1 BrS ECG generally have a good short‐term prognosis. However, managing coexisting arrhythmias in children with BrS can be challenging. Treatment should focus on the observed malignant arrhythmia, carefully monitoring side effects of anti‐arrhythmic ...
Leung HT +5 more
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Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development [PDF]
eLifeQuinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy by targeting gain-of-function KCNT1 pathogenic mutant variants.
Tian Yuan +17 more
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SYNTHETIC SUBSTITUTES FOR QUINIDINE [PDF]
British Journal of Pharmacology and Chemotherapy, 1946 G. S. Dawes
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A phase I drug–drug interaction study to assess the effect of futibatinib on P‐gp and BCRP substrates and of P‐gp inhibition on the pharmacokinetics of futibatinib [PDF]
Clinical and Translational ScienceFutibatinib, an inhibitor of fibroblast growth factor receptor 1–4, is approved for the treatment of patients with advanced cholangiocarcinoma with FGFR2 fusions/rearrangements. In this phase I drug–drug interaction study, the effects of futibatinib on P‐
Amanda Long +7 more
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The Scientific and Therapeutic Rationale for Off-Label Treatments in Amyotrophic Lateral Sclerosis. [PDF]
Ann NeurolEight alternative or off‐label treatments have been identified that all have plausible mechanisms for treating amyotrophic lateral sclerosis and some benefits in small, flawed clinical trials. Created with BioRender.com. [Color figure can be viewed at www.annalsofneurology.org] There are no dramatically effective pharmacological treatments for most ...
Bedlack R +6 more
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8-Br-cGMP activates HSPB6 and increases the antineoplastic activity of quinidine in prostate cancer [PDF]
Cell Death DiscoveryHeat shock protein family B [small] member 6 (HSPB6), widely found in various muscles, has been recently identified as a tumor suppressor gene. However, its role in prostate cancer remains unexplored.
Yuankang Feng +14 more
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Frontiers in Neurology, 2022 AimTo evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations.MethodsWe collected the data for KCNT1-related epilepsy cases from our ...
Zehong Lin +30 more
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A case report of pitfall of fever and altered mental status: cerebral malaria due to in an adult traveler returning from Congo [PDF]
Journal of Neurocritical Care, 2023 Background Cerebral malaria, caused by Plasmodium falciparum, can lead to severe neurological complications. It is more frequently observed in children than in adults.
Soo-Hyun Park +4 more
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