Results 91 to 100 of about 31,612 (240)

Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup

SAGE Open Medical Case Reports, 2020
An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder.
Yannick Villeneuve, Diana Cruz-Santiago, Helene Masson, Doris Clerc   +3 more
doaj   +1 more source

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel

iScience, 2020
Summary: Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-of-function mutations, which increase the activity of KNa1.1 sodium-activated potassium channels. Pharmacological inhibition of hyperactive KNa1.1 channels
Bethan A. Cole, Rachel M. Johnson, Hattapark Dejakaisaya, Nadia Pilati, Colin W.G. Fishwick, Stephen P. Muench, Jonathan D. Lippiat   +6 more
doaj   +1 more source

Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2018
The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann, Desiree Alisch, Brigitte Welbers-Joop, Hanns Hatt   +3 more
doaj   +1 more source

Combination of low-dose quinidine and verapamil for multifocal ectopic Purkinje-related premature contractions in a patient with SCN5A mutation

, 2023
Kei Enokizono, Satoshi Nagase, Kohei Ishibashi, Koji Miyamoto, Takeshi Aiba, Kengo Kusano   +5 more
openalex   +1 more source

How cinchona alkaloid-derived primary amines control asymmetric electrophilic fluorination of cyclic ketones. [PDF]

, 2014
The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional calculations.
Houk, KN, Lam, Yu-hong
core   +2 more sources

The effect of acute administration of quinidine, dextromethorphan and combination of dextromethorphan/quinidine on pentylenetetrazole-induced clonic and tonic seizure thresholds in mice

Fiyz̤, 2019
Background: Dextromethorphan (DM) as a non-opioid anti-cough has neuroprotective effects. Combination of DM with quinidine decreases rapid metabolism of DM to dextrorphan (DX). This study aimed to examine the effects of acute administration of quinidine,
Hassan Jamali , Azhdar Heydari
doaj  

Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system

Malaria Journal, 2010
Background Concern over the potential cardiotoxicity of anti-malarial drugs inducing a prolonged electrocardiographic QT interval has resulted in the almost complete withdrawal from the market of one anti-malarial drug - halofantrine.
Kotaki Hajime, Yamada Harumi, Kinoshita Atsushi, Kimura Mikio   +3 more
doaj   +1 more source

Reviewer #1 (Public Review): Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

, 2023
Yuan Tian, Yifan Wang, Yuchen Jin, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Hui Ying Yang, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang   +17 more
openalex   +1 more source

Effect of quinidine on electrical and motor activity of canine small bowel. [PDF]

, 1966
J M Garrett, Jerry F. Schlegel, Charles F. Code   +2 more
openalex   +1 more source

Developing an Assay to Profile Upregulated TREK-1, A Stretch-Activated Potassium Channel, in Prostate Cancer [PDF]

, 2009
Prostate cancer is the second leading cause of cancer death in American men. The disease prognosis is significantly limited by the finite therapeutic treatments.
Surber, Susan Abigal
core   +1 more source