Results 91 to 100 of about 31,065 (253)

Reducing the oral quinine-quinidine-cinchonin (Quinimax) treatment of uncomplicated malaria to three days does not increase the recurrence of attacks among children living in a highly endemic area of Senegal [PDF]

, 1996
A 3 d shortened course of the quinine-quinidine-cinchonin association Quinimax (trademark) was compared to the usual 7 d regimen for routinely treating 462 acute uncomplicated #Plasmodium falciparum$ malaria attacks in 72 children under the age of 10 ...
Brau, R., Cisse, B., Rogier, C., Tall, A., Trape, Jean-François   +4 more
core   +1 more source

Bipolar Catheter Ablation as a Key for Successful Treatment of Intramural VentricuLar Arrhythmias: Results From the Bipolar‐Kiel Study

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Unipolar catheter ablation (CA) is effective in the treatment of ventricular arrhythmias but its efficacy can be limited in eliminating intramural arrhythmic origins. Bipolar ablation has emerged as a bail‐out strategy. However, currently, it is being primarily utilized after a failed ablation attempt.
Fabian Moser, Vera Maslova, Adrian Zaman, Thomas Demming, Martina Spehlmann, Mohammed Saad, Derk Frank, Evgeny Lian   +7 more
wiley   +1 more source

Pharmacology of Antiarrhythmics: Quinidine, Beta-Blockers, Diphenylhydantoin, Bretylium [PDF]

, 1973
The electrophysiologic effects of the antiarrhythmic drugs, presented elsewhere in this symposium, form only one of the bases for the selection of a therapeutic agent in any given clinical situation.
Proctor, Jack D., Wasserman, Albert J.
core   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup

SAGE Open Medical Case Reports, 2020
An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder.
Yannick Villeneuve, Diana Cruz-Santiago, Helene Masson, Doris Clerc   +3 more
doaj   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel

iScience, 2020
Summary: Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-of-function mutations, which increase the activity of KNa1.1 sodium-activated potassium channels. Pharmacological inhibition of hyperactive KNa1.1 channels
Bethan A. Cole, Rachel M. Johnson, Hattapark Dejakaisaya, Nadia Pilati, Colin W.G. Fishwick, Stephen P. Muench, Jonathan D. Lippiat   +6 more
doaj   +1 more source

Quinidine syncope in children

Journal of the American College of Cardiology, 1987
Quinidine syncope and factors associated with it are well known among adult patients treated for cardiac arrhythmias. To define factors that may influence the occurrence of syncope in children taking quinidine, the clinical, anatomic, electrocardiographic, roentgenographic and pharmacologic data were compared in six patients with syncope (Group A) and ...
Macdonald Dick, Dennis C. Crowley, Catherine L. Webb, Amnon Rosenthal, Robert L. Spicer, Albert P. Rocchini, Robert H. Beekman, A. Rebecca Snider   +7 more
openaire   +3 more sources

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, Volume 14, Issue 10, Page 764-775, October 2025.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source