Results 91 to 100 of about 31,201 (252)

Fever as a Catalyst for Life‐Threatening Arrhythmias in Brugada Syndrome: A Rare Case of Brugada Syndrome Unmasked in a Young Male

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Brugada syndrome (BrS) is a rare, genetically predisposed arrhythmic disorder associated with an elevated risk of sudden cardiac death (SCD) due to ventricular arrhythmias. Fever is a recognized trigger that can unmask the Type 1 Brugada electrocardiogram (ECG) pattern and precipitate life‐threatening arrhythmias, even in individuals without ...
Ibrahim Khalil, Md. Imran Hossain
wiley   +1 more source

The first total synthesis of (+)-mucosin

, 2012
The first total synthesis of (+)-mucosin has been completed allowing assignment of the absolute stereochemistry of the natural product. A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous ...
Henderson, Alan R., Owen, David R., Stec, Jozef, Whitby, Richard J.   +3 more
core   +1 more source

Application of Molecular Dynamic Simulation in the Enantiorecognition Mechanism of the Pharmaceutically Relevant Leu‐Phe Dipeptides With Four Zwitterionic Chiral Stationary Phases

Journal of Separation Science, Volume 48, Issue 7, July 2025.
ABSTRACT In order to broaden the applicability of the molecular dynamics technique and to further validate the efficacy of a computational protocol recently developed in our laboratory, the present study aims to elucidate the enantiorecognition mechanisms involving four zwitterionic Cinchona alkaloid‐based CSPs under reversed‐phase (RP) conditions.
Ina Varfaj, Roccaldo Sardella, Yana A. Klimova, Leonid D. Asnin, Michael Kohout, Andrea Carotti   +5 more
wiley   +1 more source

Quinidine syncope in children

Journal of the American College of Cardiology, 1987
Quinidine syncope and factors associated with it are well known among adult patients treated for cardiac arrhythmias. To define factors that may influence the occurrence of syncope in children taking quinidine, the clinical, anatomic, electrocardiographic, roentgenographic and pharmacologic data were compared in six patients with syncope (Group A) and ...
Macdonald Dick, Dennis C. Crowley, Catherine L. Webb, Amnon Rosenthal, Robert L. Spicer, Albert P. Rocchini, Robert H. Beekman, A. Rebecca Snider   +7 more
openaire   +3 more sources

Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT In vitro data are routinely used to support both static and physiologically based pharmacokinetic (PBPK) model‐based drug–drug interaction (DDI) predictions. Such efforts are possible after years of rapid progress, enabled by the greater availability of in vitro reagents, kinetic models, and ready access to PBPK software packages with ...
David Rodrigues, Christopher R. Gibson, Nina Isoherranen   +2 more
wiley   +1 more source

A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]

, 2008
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin, Eric Howlett, Michael Stern, William Lavery   +3 more
core   +1 more source

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle [PDF]

, 1999
Objective: To study the interaction between salicylate and class 1 antiarrhythmic agents. Methods: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke ...
Hisatome, Ichiro, Igawa, Osamu, Ikeda, Kaoru, Kinugawa, Toru, Kurata, Yasutaka, Miyamoto, Jiro, Ogino, Kazuhide, Sasaki, Norihito, Sato, Ryoichi, Shigemasa, Chiaki, Tanaka, Yasunori, Urashima, Tadashi, Yamanouchi, Yumi, Yoshida, Akio   +13 more
core   +1 more source

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, Volume 115, Issue 1, Page 4-15, July 2025.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2018
The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann, Desiree Alisch, Brigitte Welbers-Joop, Hanns Hatt   +3 more
doaj   +1 more source

Orthodromic Atrioventricular Reentry Bradycardia and Tachycardia Caused by an Accessory Pathway in Horses

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Accessory pathways (APs) are muscular bundles directly connecting the atria and ventricles, bypassing the atrioventricular (AV) node‐His‐Purkinje system. Anterograde conduction along the AP results in ventricular preexcitation. A retrograde conducting AP allows ventriculo‐atrial (VA) conduction, creating a reentry circuit that ...
Eva Buschmann, Charlotte Easton‐Jones, Glenn Van Steenkiste, Hans De Wilde, Veronica Roberts, Mary Durando, Annelies Decloedt, Celia Marr, Gunther van Loon   +8 more
wiley   +1 more source