Results 101 to 110 of about 31,065 (253)

Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2018
The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann, Desiree Alisch, Brigitte Welbers-Joop, Hanns Hatt   +3 more
doaj   +1 more source

The effect of acute administration of quinidine, dextromethorphan and combination of dextromethorphan/quinidine on pentylenetetrazole-induced clonic and tonic seizure thresholds in mice

Fiyz̤, 2019
Background: Dextromethorphan (DM) as a non-opioid anti-cough has neuroprotective effects. Combination of DM with quinidine decreases rapid metabolism of DM to dextrorphan (DX). This study aimed to examine the effects of acute administration of quinidine,
Hassan Jamali , Azhdar Heydari
doaj  

Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment [PDF]

, 2017
The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic assays. Under the CiPA paradigm, the relative risk of drug-induced Torsade de Pointes (
Antzelevitch, Britton, Canty, Chézalviel-Guilbert, Colatsky, Crumb, Davison, Duff, Dutta, Efron, Elkins, Fermini, Fink, Fitzmaurice, Gintant, Guo, Hansen, Harrell, Hastie, January, January, Johnstone, Johnstone, Li, Li, Milnes, Mirams, O'Hara, Pathmanathan, Pathmanathan, Sarkar, Shotwell, Soetaert, Soetaert, Trautmann, Wickham, Yan   +36 more
core   +3 more sources

Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions

Journal of Evaluation in Clinical Practice, Volume 31, Issue 7, October 2025.
ABSTRACT Background Pharmacological therapy in older persons is inherently complex due to the interplay of age‐related physiological changes, multimorbidity, and polypharmacy. These factors increase the vulnerability of elderly patients to drug interactions and adverse drug reactions.
N. N. Ngcobo
wiley   +1 more source

Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system

Malaria Journal, 2010
Background Concern over the potential cardiotoxicity of anti-malarial drugs inducing a prolonged electrocardiographic QT interval has resulted in the almost complete withdrawal from the market of one anti-malarial drug - halofantrine.
Kotaki Hajime, Yamada Harumi, Kinoshita Atsushi, Kimura Mikio   +3 more
doaj   +1 more source

Bifunctional Organocatalysts and Brønsted Bases in Cooperative Catalysis for the Asymmetric [4 + 2] Cycloaddition of In Situ‐Generated Dienes from Isochromane‐3,4‐Diones with Nitroalkenes

Advanced Synthesis &Catalysis, Volume 367, Issue 18, September 29, 2025.
Herein, the first asymmetric [4+2] cycloaddition is reported, utilizing in situ‐generated dienes from isochromane‐3,4‐diones and nitroalkenes, catalyzed by a bifunctional thiourea organocatalyst and Brønsted base cocatalysts, yielding highly enantioselective bridged and spiro lactones, with further investigations into novel reactivity and product ...
Mohammad Sadeq Mousavi, Consiglia Tedesco, Antonio Massa   +2 more
wiley   +1 more source

Observations on the Thrombocytopenia Due to Hypersensitivity to Quinidine [PDF]

, 1954
Percy Barkham, Leandro M. Tocantins
openalex   +1 more source

THE INFLUENCE OF POTASSIUM CONCENTRATION ON THE ACTION OF QUINIDINE AND OF SOME ANTIMALARIAL SUBSTANCES ON CARDIAC MUSCLE [PDF]

, 1957
A. K. ARMITAGE
openalex   +1 more source

Thrombocytopenic Purpura Due to Quinidine [PDF]

, 1956
FREDERICK G. BOLTON
openalex   +1 more source

Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K ⁴² and Incidence of Atrial Fibrillation [PDF]

, 1958
William C. Holland, Richard L. Klein
openalex   +1 more source