Results 31 to 40 of about 31,201 (252)

Atrial Fibrillation in Eight New World Camelids. [PDF]

, 2015
BackgroundThere is limited information on the incidence of clinical signs, concurrent illness and treatment options for atrial fibrillation (AF) in New World Camelids (NWC).ObjectiveDescribe clinical signs and outcome of AF in NWC.AnimalsEight New World ...
Bozorgmanesh, R, Estell, KE, Griffiths, LG, Magdesian, KG, Stern, JA, Swain, EA   +5 more
core   +1 more source

Two South Indian children with KCNT1-related malignant migrating focal seizures of infancy – Clinical characteristics and outcome of targeted treatment with quinidine

Annals of Indian Academy of Neurology, 2019
KCNT1 gene encodes a sodium-gated potassium channel subunit that plays an important role in regulating excitability in neurons. Quinidine is a partial antagonist of this channel.
Abhijit Anil Patil, K P Vinayan, Arun Grace Roy   +2 more
doaj   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Lambiase, PD, Novak, J
core   +1 more source

Quinidine: an “Endangered Species” Drug Appropriate for Management of Electrical Storm in Brugada Syndrome

Indian Pacing and Electrophysiology Journal, 2013
Brugada syndrome is an inherited channelopathy associated with an increased risk of syncope and sudden cardiac death. In rare cases it can be manifested with electrical storm.
Stelios Paraskevaidis, MD, PhD, Efstratios K. Theofilogiannakos, MD, PhD, Vasileios Kamperidis, MD, Yiannis S. Chatzizisis, MD, PhD, Konstantinos Tsilonis, MD, Vassilios P. Vassilikos, MD, PhD, George Dakos, MD, PhD, George Stavropoulos, MD, Antonios Ziakas, MD, PhD, Stavros Hadjimiltiades, MD, PhD, Ioannis H. Styliadis, MD, PhD   +10 more
doaj   +1 more source

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. [PDF]

, 1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its ...
Antzelevitch, Blumenthal, Busch, Busch, Carmeliet, Carmeliet, Chen, Curran, Daleau, Drici, Duggal, Federico Sesti, Geoffrey W Abbott, Goldstein, Ho, Ho, Howarth, Igor Splawski, Kaczmarek, Katherine W Timothy, Lee, Lees-Miller, Liu, London, Makkar, Marianne E Buck, Mark T Keating, McDonald, Michael H Lehmann, Roden, Roden, Sanguinetti, Sanguinetti, Sanguinetti, Sanguinetti, Scamps, Schulze-Bahr, Sesti, Shibasaki, Smith, Snyders, Spector, Spector, Splawski, Splawski, Steve A.N Goldstein, Tai, Tai, Takumi, Takumi, Trudeau, Tyson, Veldkamp, Vetter, Wang, Wang, Wang, Wang, Wollnik, Yang, Yang, Yang, Yang, Zhou, Zou   +64 more
core   +1 more source

Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. [PDF]

PLoS ONE, 2015
Intestinal circulatory disturbances, atony, edema and swelling are of great clinical relevance, but the related mechanisms and possible therapeutic options are poorly characterized, in part because of the difficulties to comprehensively analyze these ...
Ingmar Lautenschläger, Inéz Frerichs, Heike Dombrowsky, Jürgen Sarau, Torsten Goldmann, Karina Zitta, Martin Albrecht, Norbert Weiler, Stefan Uhlig   +8 more
doaj   +1 more source

Mexiletine-quinidine combination: Electrophysiologic correlates of a favorable antiarrhythmic interaction in humans [PDF]

, 1987
Combination therapy with mexiletine and quinidine has been shown to be more effective than either agent alone. The ability of mexiletine monotherapy, quinidine monotherapy and mexiletine-quinidine combination therapy to suppress inducible sustained ...
Beal, Bigger, D. George Wyse, Dante Manyari, Dextrose, Duff, Duff, Duff, Greenspan, Henry J. Duff, Hoffman, Hondeghem, Hondeghem, Kelly, Kleinstiver, L. Brent Mitchell, Lab, Olsson, Sada, Saikawa, Woosley   +20 more
core   +1 more source

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

PLoS ONE, 2017
AimsShort QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr)
Cunjin Luo, Kuanquan Wang, Henggui Zhang
doaj   +1 more source

Glycine Betaine Fluxes in Lactobacillus plantarum during Osmostasis and Hyper- and Hypo-osmotic Shock [PDF]

, 1996
Bacteria respond to changes in medium osmolarity by varying the concentrations of specific solutes in order to maintain constant turgor. The primary response of Lactobacillus plantarum to an osmotic upshock involves the accumulation of compatible solutes
Glaasker, Erwin,, Konings, Wil N.,, Poolman, Bert,   +2 more
core   +2 more sources