Results 61 to 70 of about 31,201 (252)

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Organocatalytic Enantioselective Synthesis of Oxindole‐4‐Aminopyrazolone Derivatives via Mannich Reaction of 3‐Substituted Oxindoles With Pyrazolinone Ketimines

Journal of Heterocyclic Chemistry, EarlyView.
Hydroquinine‐derived squaramide catalyzes the diastereo‐ and enantioselective Mannich reaction of pyrazolinone ketimines and 3‐aryl‐substituted oxindoles to access oxindole‐4‐aminopyrazolones with vicinal tetrasubstituted stereocenters. ABSTRACT The organocatalyzed Mannich reaction between pyrazolinone ketimines and 3‐aryl‐substituted oxindoles ...
María E. Molinero, Sandra Tejedor, Laura Martín, Alicia Maestro, José M. Andrés   +4 more
wiley   +1 more source

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

Frontiers in Physiology, 2017
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of drug
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez   +5 more
doaj   +1 more source

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]

, 2005
Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ, Bray, PG, Chandler, B, Hart, CA, Hartkoorn, RC, Janneh, O, Khoo, SH, Martin, P, Owen, A, Ward, SA   +9 more
core   +1 more source

Developing a quantitative structure–property relationships (QSPR) model using Caco‐2 cell bioavailability indicators (BA) to predict the BA of phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (Papp) and efflux ratio, of 84 types of phytochemicals using Caco‐2 cell and to develop predictive model systems using machine learning with a quantitative structure–property relationship (QSPR) model ...
Kang‐Woo Lee, Dong‐Ho Lee, In‐Su Na, Jin‐Woo Kim, Na‐Yeon Lee, Jin‐Soo Park, Keunwan Park, Chau Hoang Bao Nguyen, Kyungsu Kang, Soon‐Mi Shim   +9 more
wiley   +1 more source

Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine

Neurobiology of Disease, 2000
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is characterized mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells derived from NF2 schwannomas
C. Rosenbaum, M. Kamleiter, P. Grafe, L. Kluwe, V.-F. Mautner, H.W. Müller, C.O. Hanemann   +6 more
doaj  

Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection. [PDF]

PLoS Neglected Tropical Diseases, 2018
Heme crystallization as hemozoin represents the dominant mechanism of heme disposal in blood feeding triatomine insect vectors of the Chagas disease. The absence of drugs or vaccine for the Chagas disease causative agent, the parasite Trypanosoma cruzi ...
Caroline M Ferreira, Renata Stiebler, Francis M Saraiva, Guilherme C Lechuga, Ana Beatriz Walter-Nuno, Saulo C Bourguignon, Marcelo S Gonzalez, Patrícia Azambuja, Ana Caroline P Gandara, Rubem F S Menna-Barreto, Gabriela O Paiva-Silva, Marcia C Paes, Marcus F Oliveira   +12 more
doaj   +1 more source

The effects of repetitive electric cardiac stimulation in dogs with normal hearts, complete heart block and experimental cardiac arrest [PDF]

, 1955
Direct cardiac stimulation was conducted in the open chest. In normal animals, auricular stimulation at frequencies faster than the spontaneous rate caused little change in vascular pressures or cardiac output.
GAERTNER, RA, STARZL, TE, WEBB, RC
core   +1 more source

Organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids [PDF]

, 2017
In this work, we present an organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids using arylidene azlactones as starting materials.
Martinelli, Ada
core  

Abnormal Repolarization as the Basis for Late Potentials and Fractionated Electrograms Recorded From Epicardium in Experimental Models of Brugada Syndrome [PDF]

, 2014
ObjectivesThe aim of this study was to test the hypothesis that late potentials and fractionated electrogram activity are due to delayed depolarization within the anterior aspects of right ventricular (RV) epicardium in experimental models of Brugada ...
Antzelevitch, Charles, Szél, Tamás
core   +1 more source