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Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

open access: yesFrontiers in Pharmacology, 2018
The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann   +3 more
exaly   +3 more sources

Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro

open access: yesFrontiers in Pharmacology, 2019
Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment.
X-y Zhou, Qian Liu, Guo-xin Hu
exaly   +3 more sources

The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

open access: yesFrontiers in Immunology, 2018
BackgroundBitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis ...
Alan D Workman   +2 more
exaly   +3 more sources

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

open access: yesMalaria Journal, 2011
Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more ...
Yeka Adoke   +2 more
exaly   +3 more sources

Fluorescence Analysis of Quinine in Commercial Tonic Waters [PDF]

open access: yesMethods and Protocols
Quinine is known for treating malaria, muscle cramps, and, more recently, has been used as an additive in tonic water due to its bitter taste. However, it was shown that excessive consumption of quinine can have severe side effects on health.
Artturi Harcher   +15 more
doaj   +2 more sources

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