Results 1 to 10 of about 70,444 (211)

Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2018
The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann, Desiree Alisch, Brigitte Welbers-Joop, Hanns Hatt   +3 more
doaj   +2 more sources

Synthesis and Biological Activity of Novel Polyazaheterocyclic Derivatives of Quinine [PDF]

Molecules
A synthetic methodology of the CuAAC “click” approach was exploited for the construction of 1,2-azolyltriazole quinine derivatives by the reaction of O-propargylquinine with azidomethyl-1,2-azoles in methanol.
Gulim K. Mukusheva, Nurizat N. Toigambekova, Roza B. Seidakhmetova, Roza I. Jalmakhanbetova, Mukhlissa N. Babakhanova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Evgenij A. Dikusar, Irina A. Kolesnik, Hongwei Zhou, Vladimir I. Potkin   +10 more
doaj   +2 more sources

Research Note: Evaluation of quinine as a chemoprophylactic candidate against histomoniasis in turkeys

Poultry Science, 2021
: Histomoniasis, also commonly referred to as blackhead disease, is caused by the protozoan parasite Histomonas meleagridis. Since the removal of nitarsone in 2015, no approved prophylactics are available for mitigating histomoniasis.
L.C. Beer, B.M. Hargis, C.N. Vuong
doaj   +1 more source

Aptamer-based nanotrains and nanoflowers as quinine delivery systems

International Journal of Pharmaceutics: X, 2023
In this study, we designed aptamer-based self-assemblies for the delivery of quinine. Two different architectures were designed by hybridizing quinine binding aptamers and aptamers targeting Plasmodium falciparum lactate dehydrogenase (PfLDH): nanotrains
Mengyuan Cao, Anthony Vial, Laetitia Minder, Aurore Guédin, Sébastien Fribourg, Laurent Azéma, Cécile Feuillie, Michael Molinari, Carmelo Di Primo, Philippe Barthélémy, Leblond Chain Jeanne   +10 more
doaj   +1 more source

Aversion to Quinine is Associated with Taste Sensation in Chicks

The Journal of Poultry Science, 2005
Quinine is known as a bitter compound for humans and also used in animal experiment. However, there is no evidence that animals share the same taste sensation of quinine with humans.
Hiroshi Ueda, Saori Kainou
doaj   +1 more source

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

BMC Pharmacology and Toxicology, 2018
Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD).
Hadi Molanaei, Abdul Rashid Qureshi, Olof Heimbürger, Bengt Lindholm, Ulf Diczfalusy, Björn Anderstam, Leif Bertilsson, Peter Stenvinkel   +7 more
doaj   +1 more source

Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction [PDF]

Journal of Pure and Applied Chemistry Research, 2020
Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development.
Teni Ernawati , Minarti Minarti, Puspa Dewi Narrij Lotulung   +2 more
doaj  

Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

Malaria Journal, 2012
Background The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved.
Bohórquez Elaine B, Chua Michael, Meshnick Steven R   +2 more
doaj   +1 more source

Physiologically based pharmacokinetic modeling for dose optimization of quinine–phenobarbital coadministration in patients with cerebral malaria

CPT: Pharmacometrics & Systems Pharmacology, 2022
Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions.
Teerachat Sae‐heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang, Kesara Na‐Bangchang   +4 more
doaj   +1 more source

Using Quinine as a Fluorescent Tracer to Estimate Overland Flow Velocities on Bare Soil: Proof of Concept under Controlled Laboratory Conditions

Agronomy, 2021
This study presents a tracer technique based on the fluorescent properties of quinine to help on the visualization of shallow flows and allow a quantitative measurement of overland flow velocities.
João L. M. P. de Lima, Soheil Zehsaz, M. Isabel P. de Lima, Jorge M. G. P. Isidoro, Romeu Gerardo Jorge, Ricardo Martins   +5 more
doaj   +1 more source