Results 11 to 20 of about 129,805 (284)
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
Frontiers in Pharmacology, 2019 Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment.
Xiao-Yang Zhou +7 more
doaj +2 more sources
Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors
Frontiers in Pharmacology, 2018 The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann +3 more
doaj +2 more sources
Frontiers in Immunology, 2018 BackgroundBitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis ...
Alan D. Workman +14 more
doaj +2 more sources
Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2
Viruses, 2021 While vaccination campaigns are ongoing worldwide, there is still a tremendous medical need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates, chloroquine (CQN) and hydroxychloroquine (H-CQN) were tested intensively ...
Maximilian Große +12 more
doaj +2 more sources
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Malaria Journal, 2011 Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more ...
Baliraine Frederick N +7 more
doaj +2 more sources
Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine
Cellular Physiology and Biochemistry, 2016 Background/Aims: The analkaloid drug quinine is utilized mainly for the chemoprophylaxis of malaria. The multiple side effects of quinine include hemolytic anemia and hemolytic uremic syndrome, disorders involving suicidal erythrocyte death or eryptosis,
Morena Mischitelli +4 more
doaj +2 more sources
The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors.
PLoS ONE, 2016 Bitter taste is one of the five basic taste sensations which is mediated by 25 bitter taste receptors (T2Rs) in humans. The mechanism of bitter taste signal transduction is not yet elucidated.
Jasbir D Upadhyaya +5 more
doaj +2 more sources
In Silico ADME/T Properties of Quinine Derivatives using SwissADME and pkCSM Webservers
International Journal of TROPICAL DISEASE & Health, 2021 Aim: Malaria is among the most devastating and widespread tropical parasitic diseases. To overcome antimalarial drug resistance, new drugs need to be developed.
Jean Gonfi M. Mvondo +5 more
semanticscholar +1 more source
Early and Late Steps of Quinine Biosynthesis
Organic Letters, 2021 The enzymatic basis for quinine 1 biosynthesis was investigated. Transcriptomic data from the producing plant led to the discovery of three enzymes involved in the early and late steps of the pathway.
F. Trenti +5 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Polymer-based vehicles that controllably deliver therapeutic nucleic acids to cells show great potential to develop safe and effective gene therapies. Realizing this potential, however, is limited by the lack of understanding of how polymers
Craig Van Bruggen +6 more
semanticscholar +1 more source