Results 21 to 30 of about 129,805 (284)
Chemical Sensors, 2020 Genetic variability in the ability to taste thiourea compounds has been studied for 80+ years. Over the last 3 decades, many studies have reported perceived intensity of concentrated propylthiouracil (PROP) associates with greater intensity from a broad ...
A. A. Nolden, J. McGeary, J. Hayes
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Antimicrobial activity of quinine derivatives against human pathogenic bacteria
IOP Conference Series: Earth and Environment, 2020 Nowadays, the antimicrobial resistance is considered as one of the greatest concern facing human health, as many of bacterial strains had become resistant to available antibiotics.
L. Antika, D. Triana, T. Ernawati
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Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients
BMC Pharmacology and Toxicology, 2018 Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD).
Hadi Molanaei +7 more
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Science Translational Medicine, 2019 A cellular thermal shift assay (CETSA) protocol identifies and resolves antimalarial drug targets in P. falciparum. Defining drug targets in malaria Different classes of malaria drugs have been used for decades, even though the mechanisms of action have ...
J. Dziekan +9 more
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Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction [PDF]
Journal of Pure and Applied Chemistry Research, 2020 Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development.
Teni Ernawati +2 more
doaj
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil [PDF]
, 2008 We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline
BORGES, Larissa Maria Guimarães +3 more
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Malaria Journal, 2012 Background The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved.
Bohórquez Elaine B +2 more
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CPT: Pharmacometrics & Systems Pharmacology, 2022 Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions.
Teerachat Sae‐heng +4 more
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Agronomy, 2021 This study presents a tracer technique based on the fluorescent properties of quinine to help on the visualization of shallow flows and allow a quantitative measurement of overland flow velocities.
João L. M. P. de Lima +5 more
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Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]
, 2013 The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
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