Results 41 to 50 of about 107,358 (282)
Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]
, 2013 The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core +1 more source
Some taste substances are direct activators of G-proteins [PDF]
, 1994 Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins.
Grünbaum, L. +4 more
core +3 more sources
PharmaceuticsObjectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in ...
Tamara Ramos Maciel +6 more
doaj +1 more source
Mefloquine resistant malaria in cameroon and correlation with resistance quinine
Memorias do Instituto Oswaldo Cruz, 1992 Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur +3 more
doaj +1 more source
A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]
PLoS Genetics, 2014 The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez +8 more
doaj +1 more source
Quinoline Antimalarials Increase the Antibacterial Activity of Ampicillin
Frontiers in Microbiology, 2021 Bacterial and malaria co-infections are common in malaria endemic countries and thus necessitate co-administration of antibiotics and antimalarials. There have long been anecdotal clinical reports of interactions between penicillins and antimalarial ...
Olajumoke A. Olateju +9 more
doaj +1 more source
JAMA: The Journal of the American Medical Association, 1899 A perusal of current literature and an experience with physicians in active practice show many differences of opinion regarding the use and value of quinin in various malarial diseases. The recent war, by exposing large numbers of men to real or imaginary malaria, brought out in a striking manner many of the most common views, and the numerous articles
openaire +3 more sources
Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine
Cellular Physiology and Biochemistry, 2016 Background/Aims: The analkaloid drug quinine is utilized mainly for the chemoprophylaxis of malaria. The multiple side effects of quinine include hemolytic anemia and hemolytic uremic syndrome, disorders involving suicidal erythrocyte death or eryptosis,
Morena Mischitelli +4 more
doaj +1 more source