Results 51 to 60 of about 129,805 (284)

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa, Appolinary Ar, Silumbe, Richard   +1 more
core   +2 more sources

New Insights into Quinine-DNA Binding Using Raman Spectroscopy and Molecular Dynamics Simulations.

Journal of Physical Chemistry B, 2018
Quinine's ability to bind DNA and potentially inhibit transcription and translation has been examined as a mode of action for its antimalarial activity.
David Punihaole, Riley J Workman, Shiv Upadhyay, Craig Van Bruggen, Andrew J. Schmitz, T. Reineke, R. Frontiera   +6 more
semanticscholar   +1 more source

Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in Plasmodium berghei-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

Pharmaceutics
Objectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in ...
Tamara Ramos Maciel, Ana Claudia Funguetto-Ribeiro, Laura Ben Olivo, Flávia Elizabete Guerra Teixeira, Camila de Oliveira Pacheco, Bibiana Verlindo de Araujo, Sandra Elisa Haas   +6 more
doaj   +1 more source

A complex relationship among chemical concentration, detection threshold and suprathreshold intensity of bitter compounds

, 2007
Detection thresholds and psychophysical curves were established for caffeine, quinine-HCl (QHCl), and propylthiouracil (PROP) in a sample of 33 subjects (28 female mean age 24 ± 4).
Adler, Bachmanov, Bartoshuk, BARTOSHUK, Bufe, Caicedo, Chandrashekar, Duffy, Frank, Galindo-Cuspinera, Green, Green, Huang, J. Roper, Jones, Katz, Keast, Keast, Kinnamon, Lawless, McLaughlin, Mojet, Mueller, Ottinger, Peri, P  rez, R. S. J. Keast, Rosenzweig, R  ssler, Small, Yokomukai   +30 more
core   +1 more source

Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Revista Brasileira de Parasitologia Veterinária, 2021
Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting in significant economic losses. There is no commercial treatment for neosporosis, and drug repositioning is a fast strategy to test possible candidates against N ...
Luiz Miguel Pereira, Gabriela de Luca, Nathália de Lima Martins Abichabki, Jade Cabestre Venancio Brochi, Luciana Baroni, Péricles Gama Abreu-Filho, Ana Patrícia Yatsuda   +6 more
doaj   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source

Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
Moderate exercise and low‐dose ellagic acid supplementation improved motor performance, learning, and longevity in a transgenic Drosophila model of Alzheimer's disease. Both interventions showed hormetic effects—that is, beneficial at low levels, but detrimental at higher intensities or doses.
Michelle Morgan, Zaida Lopez Rodriguez, Richard E. Hartman   +2 more
wiley   +1 more source

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. [PDF]

, 2018
GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some ...
Conlisk, Dana, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kimbrough, Adam, Kononoff, Jenni   +5 more
core  

Synthesis of (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol Tetraphenylborate Ion-Pair Complex: Characterization, Antimicrobial, and Computational Study

Molecules, 2023
The (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol (quinine)-tetraphenylborate complex was synthesized by reacting sodium tetraphenyl borate with quinine in deionized water at room temperature through an ion-pair reaction ...
Tarek A. Yousef, Haitham Alrabiah, Mohamed H. Al-Agamy, Rashad Al-Salahi, Essam A. Ali, Gamal A. E. Mostafa   +5 more
doaj   +1 more source

Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX

Platelets, 2019
Drug-induced Immune thrombocytopenia (DIT) is a common complication of several medications, including commonly used antibiotics. The most widely studied DIT is caused by quinine. In DIT, antibodies predominantly bind to the platelet membrane glycoprotein
Zohra Ahmadi, Jose Perdomo, Rose Wong, Beng H Chong   +3 more
doaj   +1 more source