Results 191 to 200 of about 36,461 (237)
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Norfloxacin: A Quinoline Antibiotic
Drug Intelligence & Clinical Pharmacy, 1986Norfloxacin is a quinoline (quinolinecarboxylic acid) that should prove successful in treating infections that currently require hospitalization and intravenous antibiotics. Although a nalidixic acid derivative, it possesses greater antibacterial activity against gram-positive and gram-negative bacteria.
D A, Marble, J A, Bosso
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Comparative mutagenesis of quinolines
Mutation Research/Reviews in Genetic Toxicology, 1977Abstract Quinoline, 8-hydroxyquinoline, 8-nitroquinoline, and 8-aminoquinoline are mutagenic in Salmonella when assayed by histidine reversion. Metabolic activation is required for the maximal effect. Frameshift mutagenesis appears to be the mechanism with 8-nitro- and 8-aminoquinoline. Quinoline and 8-hydroxyquinoline affect only the sensitive TA100
J L, Epler +5 more
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Current Medicinal Chemistry, 2010
Although the assortment of antifungal drugs is broad, the most commonly used agents have major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are amongst them. New drugs and drug candidates under clinical trials do not guarantee better pharmacological parameters. These new medicines may appear effective; however; they may
R, Musiol +3 more
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Although the assortment of antifungal drugs is broad, the most commonly used agents have major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are amongst them. New drugs and drug candidates under clinical trials do not guarantee better pharmacological parameters. These new medicines may appear effective; however; they may
R, Musiol +3 more
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Effect of quinolinate on aminotransferases
Archives of Biochemistry and Biophysics, 1976Abstract Quinolinate inhibits several aminotransferases (ornithine, alanine, and aspartate). However, it is considerably more potent as an inhibitor of liver and heart cytoplasmic aspartate aminotransferase. It is a much less potent inhibitor of mitochondrial aspartate aminotransferases.
S L, Hsu, L A, Fahien
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Friedländer Quinoline Synthesis
2009Also known as the Friedlander condensation, it combines an α-amino aldehyde or ketone with another aldehyde or ketone with at least one methylene α adjacent to the carbonyl to furnish a substituted quinoline. The reaction can be promoted by either acid, base, or heat.
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A state-of-the-art review of quinoline degradation and technical bottlenecks
Science of the Total Environment, 2020Aijuan Zhou, Xin Kong
exaly