Results 91 to 100 of about 19,883 (275)

New synthetic approach to epoxyisoindolo[2,1-a]quinolines based on cycloaddition reactions of 2-furyl-substituted tetrahydroquinolines with maleic anhydride and acryloyl chloride

, 2020
A procedure was developed for the synthesis of hydrogenated furyl-substituted furo[3,2-c]quinolines, pyrano[3,2-c]quinolines, and 4-ethoxy-and 4-(2-oxopyrrolidin-1-yl)quinolines.
Peregudov A.S., Zaitsev V.P., Zubkov F.I., Mikhailova N.M., Varlamov A.V.   +4 more
core   +2 more sources

FUSED 1,2,4-TRIAZOLE HETEROCYCLES. II: REACTION OF 2-CHLORO-3-(1,3-DIOXOLAN- 2-YL)QUINOLINES WITH 1,2,4-TRIAZOLE-5THIOL

, 1995
Reaction of 2-chloro-3-(1,3-dioxolan-2-yl)quinolines 1 with 1,2,4-triazole-5-thiol 2 leads to the formation of a mixture of 11-(2-hydroxyethyl)oxy-11H-[1,2,4]triazolo[5',1':2,3][1,3]thiazino[6,5-b]quinolines 3 and 11-(2-hydroxyethyl)oxy-11/-/-[1,2,4 ...
Szabó, Zoltan,, Cziaky, Z., Ferenc Kóródi, Zoltán Szabo, Zoltán Cziaky, Kćrćdi, F.   +5 more
core   +1 more source

5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors

Molecules, 2015
A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer of Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery of 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1 ...
Pu Xiang, Hui Jie, Yang Zhou, Bo Yang, Hui-Juan Wang, Jing Hu, Jian Hu, Sheng-Yong Yang, Ying-Lan Zhao   +8 more
doaj   +1 more source

Novel approach to isoindolo[2,1-a]quinolines

, 1998
International audienceAn N-acyliminium ion approach towards the synthesis of isoindolo [2,1-a]quinolines by an intramolecular process is ...
Decroix, Bernard, Pigeon, Pascal
core   +1 more source

Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

Beilstein Journal of Organic Chemistry, 2011
The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence.
Esther Vicente-García, Rosario Ramón, Sara Preciado, Rodolfo Lavilla   +3 more
doaj   +1 more source

Synthesis, Characterization, and In Vitro Evaluation of New Amino‐Alcohol Quinolines as Promising Antimycobacterial Agents [PDF]

ChemMedChem
Nontuberculous mycobacteria (NTM) mainly Mycobacterium avium complex (MAC), are emerging pathogens responsible for pulmonary infections. The efficacy of the standard treatment is therefore compromised by the emergence of intrinsic and acquired resistance in MAC.
Si Ahmed Charrier E, Peltier F, Raimbert J, Perret M, Andréjak C, Dassonville‐Klimpt A, Sonnet P.   +6 more
europepmc   +2 more sources

Metal-Free, Ionic Liquid-Mediated Synthesis of Functionalized Quinolines

, 2016
An expedient and metal-free synthetic protocol for construction of substituted quinolines has been developed from anilines and phenylacetaldehydes using imidazolium cation-based ionic liquids as the reaction medium.
Sandip B. Bharate (1575007), Jaideep B. Bharate (1724008), Ram A. Vishwakarma (657373)   +2 more
core   +1 more source

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial metalloenzymes that are involved in diverse bioprocesses. We report the synthesis and biological evaluation of novel series of benzenesulfonamides incorporating un/substituted ethyl quinoline-3 ...
Mohammad M. Al-Sanea, Ahmed Elkamhawy, Sora Paik, Silvia Bua, So Ha Lee, Mohamed A. Abdelgawad, Eun Joo Roh, Wagdy M. Eldehna, Claudiu T. Supuran   +8 more
doaj   +1 more source

General Pathway for a Convenient One-Pot Synthesis of Trifluoromethyl-Containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and Fused Cycloalkane Analogues

Molecules, 2011
A convenient and general method for the synthesis in 26–73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF3C(O)CH=C(R1)
Marcos A. P. Martins, Nilo Zanatta, Nícolas Krüger, Rosália Andrighetto, Helio G. Bonacorso   +4 more
doaj   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source