Results 101 to 110 of about 12,837 (198)

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

Quinolines: the role of substitution site in antileishmanial activity. [PDF]

Front Chem
Elso OG, García Liñares G.
europepmc   +1 more source

Recent Advances in Photoelectrochemical Water Splitting Enabled by Covalent Organic Frameworks

Small Structures, Volume 7, Issue 6, June 2026.
This review highlights the potential of 2D covalent organic frameworks (COFs) as tunable and porous photoactive catalysts for solar‐driven water splitting. It discusses COF design principles and emerging photoelectrocatalytic performance, with special emphasis on film fabrication and deposition strategies critical for integrating COFs into efficient ...
Roman Guntermann, Shuo Sun, Jonathan Kampmann, Dana D. Medina   +3 more
wiley   +1 more source

Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation? [PDF]

Front Chem
Romero AH.
europepmc   +1 more source

Patch Testing in Individuals With Diabetes Using Medical Devices. Part 1—Contact Allergy to Baseline Series Allergens

Contact Dermatitis, Volume 94, Issue 6, Page 624-634, June 2026.
The contact allergy prevalence in individuals with diabetes and in diabetes medical device (MD) users is unknown. This study in 204 diabetes MD users (114 with rash to diabetes MDs, 90 without) aimed at investigating the contact allergy prevalence to baseline series allergens. Contact allergies to sesquiterpene lactone mix and myroxylon pereirae resin (
Thanisorn Sukakul, Josefin Ulriksdotter, Martin Mowitz, Magnus Bruze, Nils Hamnerius, Cecilia Svedman   +5 more
wiley   +1 more source

Fe-catalyzed efficient synthesis of 2,4- and 4-substituted quinolines via C(sp²)-C(sp²) bond scission of styrenes. [PDF]

Beilstein J Org Chem
Jagtap PA, Petkar MM, Sawant VR, Bhanage BM.   +3 more
europepmc   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source

Pyridine-boryl radical mediated synthesis of quinolines <i>via</i> α-amino radical formation and intramolecular alkenyl sulfone trapping.

Org Chem Front
Valderrama-Callejón R, Alonso I, Gómez S, Jiménez D, Dorado-Briones G, Vargas EL, Tortosa M, Cid MB.   +7 more
europepmc   +1 more source

Site-Selective C6-β-Aminoalkylation of Tetrahydroquinolines with N-Arylsulfonyl Aryl Aziridines in Hexafluoroisopropanol: A Modular Approach to C6-Alkylated Quinolines. [PDF]

J Org Chem
Taskesenligil Y, Aslan M, Saracoglu N.
europepmc   +1 more source