Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes [PDF]
, 2019 Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited ...
Fishman, DA +3 more
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Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance [PDF]
, 2016 Antimalarial chloroquine (CQ) prevents haematin detoxication when CQ-base concentrates in the acidic digestive vacuole through protonation of its p-aminopyridine (pAP) basic aro- matic nitrogen and sidechain diethyl-N.
A Avdeef +27 more
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Molecules, 2018 A small library of novel quinoline-3-carbaldehyde hydrazones (Series 1), acylhydrazones (Series 2), and arylsulfonylhydrazones (Series 3) bearing either a 1,2,4-triazole or benzotriazole ring at position 2 was prepared, characterized by elemental ...
Martyna Korcz +3 more
doaj +1 more source
Asymmetric synthesis of tetrahydroquinolines via aza-Michael reactions
, 2012 The tetrahydroquinolines structural unit is found in a number of natural products that exhibit a variety of biological activities including anti-allergic, anti-inflammatory and antitumour.
Taylor, Laura, Taylor, Laura
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Biphenyl-bridged 6-(1-aryliminoethyl)-2-iminopyridyl-cobalt complexes: synthesis, characterization and ethylene polymerization behavior [PDF]
, 2014 A series of biphenyl-bridged 6-(1-aryliminoethyl)-2-iminopyridine derivatives reacted with cobalt dichloride in dichloromethane/ethanol to afford the corresponding binuclear cobalt complexes.
Du, Shizhen +6 more
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Animal Research and One Health, EarlyView.Activo Liquid and Halquinol inhibit Salmonella and Escherichia coli in culture media. Activo Liquid exhibits bactericidal action, whereas HA is bacteriostatic, and their combination results in positive or indifferent interactions. This combination effectively inhibits E. coli throughout digestion simulation, thus reducing the required concentrations of
Alberto Gonçalves Evangelista +6 more
wiley +1 more source
Organocatalytically Generated Donor − Acceptor Cyclopropanes in Domino Reactions. One-Step Enantioselective Synthesis of Pyrrolo[1,2 ‑ a ]quinolines [PDF]
, 2016 An easy and straightforward procedure has been developed for the synthesis of highly enantioenriched pyrrolo-[1,2-a]quinolines through a one-pot process that comprises a domino cyclopropane ring opening/aza-Michael/aldol reaction followed by acid ...
Carrillo Fernández, María Luisa +5 more
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Bulletin of the Korean Chemical Society, EarlyView.Mechanistic studies reveal that hexafluoroisopropanol (HFIP) enables C–Cl activation of propargylic halides by stabilizing ion pairs and enhancing effective Brønsted acidity. This cooperative solvent effect allows access to cationic intermediates and promotes cascade formation of tetrahydroquinolines through cyclization and disproportionation ...
Seung Hoon Lee, Hyung Min Chi
wiley +1 more source
NITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1995 Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-
doaj
Supramolecular study, Hirshfeld analysis and theoretical study of 6-methoxyquinoline N-oxide dihydrate [PDF]
, 2013 In the crystal structure of 6-methoxyquinoline N-oxide dihydrate, C10H9NO2 center dot 2H(2)O, (I), the presence of two-dimensional water networks is analysed.
Hernandez, Geraldine +3 more
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