Results 121 to 130 of about 26,162 (241)

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Chiral N-acyliminium ions as new tools in the asymmetric synthesis of CNS-active compounds [PDF]

, 1994
Beutler, Comins, Gray, Hellmann, Irie, K.Th. Wanner, Kiguchi, Wanner, Wanner, Wong   +9 more
core   +1 more source

Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents

Pest Management Science, EarlyView.
A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos, Patricia V. Pietrantonio   +1 more
wiley   +1 more source

A novel water‐soluble near‐infrared fluorescent probe for monitoring viscosity fluctuations in plants and zebrafish under abiotic stresses

Smart Molecules, EarlyView.
HJA‐MQ‐D exhibits a rapid and sensitive response to viscosity changes based on the twisted intramolecular charge transfer mechanism. Displaying near‐infrared emission and excellent water‐solubility, enabling imaging at the cellular and whole plant level.
Yixue Feng, Keke Ding, Yongxu Yang, Quanliang Liu, Silin Xu, Chunhui Liu, Zhihong Xu, Xufeng Hou, Jihong Huang, Tony D. James   +9 more
wiley   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, EarlyView.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

Nickel Foam Electrodes—A Versatile, Powerful, and Readily Available Tool in Electro‐Organic Synthesis

The Chemical Record, EarlyView.
Nickel foam—one material, two faces, and several versatile roles depending on electrolytic conditions. For more than 50 years, nickel foam electrodes have served in electrosynthesis as powerful and readily available electrode materials. Due to their inexpensive nature and easy handling, they have been widely employed.
Rok Narobe, Johannes Schneider, Siegfried R. Waldvogel   +2 more
wiley   +1 more source

Tuning the Photochemistry of Entatic State Model Systems

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
We present the photochemistry of the entatic state model [Cu(DMEGqu)2]+/2+, a copper guanidino‐quinoline complex pair. By transient IR and UV/Vis spectroscopy, we obtained the lifetimes of the different excited states. We show that the structural effect of the guanidine tunes the photochemistry of this entatic state model.
Alexander Hoffmann, Julia Stanek, Stefan Hofmann, Michael Rampp, Benjamin Maerz, Benjamin Grimm‐Lebsanft, Melissa Kindler, Tobias Seitz, Michael Rübhausen, Wolfgang Zinth, Sonja Herres‐Pawlis   +10 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Patch Testing in Individuals With Diabetes Using Medical Devices. Part 1—Contact Allergy to Baseline Series Allergens

Contact Dermatitis, EarlyView.
The contact allergy prevalence in individuals with diabetes and in diabetes medical device (MD) users is unknown. This study in 204 diabetes MD users (114 with rash to diabetes MDs, 90 without) aimed at investigating the contact allergy prevalence to baseline series allergens. Contact allergies to sesquiterpene lactone mix and myroxylon pereirae resin (
Thanisorn Sukakul, Josefin Ulriksdotter, Martin Mowitz, Magnus Bruze, Nils Hamnerius, Cecilia Svedman   +5 more
wiley   +1 more source