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Excitotoxicity of Kainic acid and quinolinic acid: animal and tissue culture studies

, 1997
Ewa Matyja
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Quinoline-4-carboxylic Acid

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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A radioenzymatic assay for quinolinic acid

Analytical Biochemistry, 1986
A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
A C, Foster, E, Okuno, D S, Brougher, R, Schwarcz   +3 more
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Quinolinic Acid Phosphoribosyltransferase in Rat Brain

Journal of Neurochemistry, 1985
Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
A C, Foster, W C, Zinkand, R, Schwarcz
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Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
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Brain quinolinic acid in Alzheimer's dementia

European Archives of Psychiatry and Neurological Sciences, 1989
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic, J, Halket, A, Przyborowska, P, Riederer, H, Beckmann, M, Sandler, K, Jellinger   +6 more
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Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds, S J, Pearson, J, Halket, M, Sandler   +3 more
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