Results 181 to 190 of about 15,449 (218)
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The quinolinic acid hypothesis in Huntington's chorea
Journal of the Neurological Sciences, 1990In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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Quinolinic acid in children with congenital hyperammonemia
Annals of Neurology, 1993AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw +4 more
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Quinolinic Acid and Active Oxygens
1996Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983).
K. Goda +4 more
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Quinolinic Acid: A Pathogen in Seizure Disorders?
1986The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz +4 more
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Derivatives Of Quinoline-3-carboxylic Acid And Benzo(f)quinoline-2- Carboxylic Acid.
1950PhD ; Pharmacology ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/182998/2/0002401 ...
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Quinolinic Acid Accumulation During Neuroinflammation
Annals of the New York Academy of Sciences, 2001Abstract:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist ofN‐methyl‐d‐aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation.
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Oligodendrocyte killing by quinolinic acid in vitro
Brain Research, 2001Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
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