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L-carnitine modulates molecular responses associated with inflammation, endoplasmic reticulum stress, and neurotrophic signaling in cerebral cortex of neonatal Gcdh^-/- mice exposed to glutaric and quinolinic acids. [PDF]

Metab Brain Dis
Castro ET, Zanatta Â, Carvalho AVS, de Moraes AU, Netto CA, Leipnitz G, Amaral AU, Vargas CR, Ribeiro RT, Wajner M.   +9 more
europepmc   +1 more source

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A radioenzymatic assay for quinolinic acid

Analytical Biochemistry, 1986
A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
Robert Schwarcz, Etsuo Okuno, A C Foster   +2 more
exaly   +3 more sources

Quinolinic Acid Phosphoribosyltransferase in Rat Brain

Journal of Neurochemistry, 1985
Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
Robert Schwarcz, A C Foster
exaly   +3 more sources

Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture

Journal of Pineal Research, 2005
Quinolinic acid is a well-known excitotoxin that induces oxidative stress and damage. In the present study, oxidative damage to biomolecules was followed by measuring lipid peroxidation and protein carbonyl formation in rat brain tissue culture over a ...
Cristina Tomás-Zapico, Burkhard Poeggeler, Ana Coto-Montes   +2 more
exaly   +2 more sources

Quinoline-4-carboxylic Acid

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain

1991
Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid

Biochemical and Biophysical Research Communications, 1988
The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
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A photometric method for the determination of quinolinic acid

Archives of Biochemistry and Biophysics, 1953
Abstract 1. 1. A photometric method is described for the determination of quinolinic acid in trichloroacetic acid extracts of tissue preparations which have metabolized 3-hydroxyanthranilic acid. 2. 2. The method is based on the measurement of the stable yellow color of the ferrous chelate of quinolinic acid.
M, RABINOVITZ, R A, FINEBERG, D M, GREENBERG   +2 more
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Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
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The quinolinic acid hypothesis in Huntington's chorea

Journal of the Neurological Sciences, 1990
In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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