Results 1 to 10 of about 880,028 (202)

Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment [PDF]

Brain, Behavior, & Immunity - Health
Activation of the kynurenine pathway (KP) with resulting accumulation of neuroactive metabolites may be a downstream pathophysiological mechanism of inflammatory depression.
Jesper Lindahl, Gustav Söderberg Veibäck, Klara Suneson, Wilma Blanking, Johanna Tjernberg, Darya Ståhl, Åsa Wiman, Filip Ventorp, Sophie Erhardt, Daniel Lindqvist   +9 more
doaj   +2 more sources

Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction [PDF]

BMC Microbiology
Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear.
Yi Ru, Ying Yu, Chuanxin Liu, Yunge Liu, Dongxia Liu, Ruyan Chen, Xiaowan Chen, Xiaoyang Bai, Tao Jiang, Jiajia Duan   +9 more
doaj   +2 more sources

“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
doaj   +1 more source

Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model

Journal for ImmunoTherapy of Cancer, 2022
Background Amino acid metabolism is essential for tumor cell proliferation and regulation of immune cell function. However, the clinical significance of free amino acids (plasma-free amino acids (PFAAs)) and tryptophan-related metabolites in plasma has ...
Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani   +15 more
doaj   +1 more source

Zwitterionic or Not? Fast and Reliable Structure Determination by Combining Crystal Structure Prediction and Solid-State NMR

Molecules, 2023
When it comes to crystal structure determination, computational approaches such as Crystal Structure Prediction (CSP) have gained more and more attention since they offer some insight on how atoms and molecules are packed in the solid state, starting ...
Federica Bravetti, Raffaele E. Russo, Simone Bordignon, Angelo Gallo, Federica Rossi, Carlo Nervi, Roberto Gobetto, Michele R. Chierotti   +7 more
doaj   +1 more source

8-HQA adjusts the number and diversity of bacteria in the gut microbiome of Spodoptera littoralis

Frontiers in Microbiology, 2023
Quinolinic carboxylic acids are known for their metal ion chelating properties in insects, plants and bacteria. The larval stages of the lepidopteran pest, Spodoptera littoralis, produce 8-hydroxyquinoline-2-carboxylic acid (8-HQA) in high concentrations
Tilottama Mazumdar, Sabine Hänniger, Shantanu P. Shukla, Aishwarya Murali, Stefan Bartram, David G. Heckel, Wilhelm Boland   +6 more
doaj   +1 more source

Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection

Virology Journal, 2023
Background Influenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a highly contagious disease that can be deadly, especially in high-risk groups.
Huda A. M. Al-Shalan, Lu Zhou, Zhifan Dong, Penghao Wang, Philip K. Nicholls, Berin Boughton, Philip A. Stumbles, Wayne K. Greene, Bin Ma   +8 more
doaj   +1 more source

Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine. [PDF]

PLoS ONE, 2016
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify ...
Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Oguz Mutlu, Gilles J Guillemin, Catherine Belzung, Pascal R Barone   +6 more
doaj   +1 more source

Effect of Dietary Acrylamide Exposure on Blood Glucose Metabolism and Organ Functions of Type 2 Diabetic GK Rats [PDF]

Shipin Kexue, 2023
Objective: To investigate the effect of dietary acrylamide exposure on the progression of type 2 diabetes in GK rats. Methods: The effects of intragastric administration of acrylamide (2 mg/(kg mb·d)) for eight weeks on blood glucose metabolism ...
XIE Yiting, PENG Fei, LOU Aihua, SHEN Qingwu, CHEN Jie, QUAN Wei
doaj   +1 more source

Systemic long-term metabolic effects of acute non-severe paediatric burn injury

Scientific Reports, 2022
A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity.
Sofina Begum, Blair Z. Johnson, Aude-Claire Morillon, Rongchang Yang, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Leila Cuttle, Andrew J. A. Holland, Jeremy K. Nicholson, Fiona M. Wood, Mark W. Fear, Elaine Holmes   +13 more
doaj   +1 more source