Results 1 to 10 of about 4,572 (161)

Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment [PDF]

Brain, Behavior, & Immunity - Health
Activation of the kynurenine pathway (KP) with resulting accumulation of neuroactive metabolites may be a downstream pathophysiological mechanism of inflammatory depression.
Jesper Lindahl, Gustav Söderberg Veibäck, Klara Suneson, Wilma Blanking, Johanna Tjernberg, Darya Ståhl, Åsa Wiman, Filip Ventorp, Sophie Erhardt, Daniel Lindqvist   +9 more
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Wuwei Jianpi San Improves Growth Performance and Immune Status in Yaks Through Modulation of Rumen Microbiota and Host Metabolism [PDF]

Animals
To investigate the effects of Wuwei Jianpi San (WJPS), a Chinese herbal compound feed additive, on rumen microecology, host metabolism, and immune function in healthy yaks (Bos grunniens), and to determine the optimal supplementation level, 32 yaks with ...
Ke Zhou, Hongmei Shi, Xiangying Kong, Weidong Ma, Jianguo Kang, Haizhong Che, Yongli Hua   +6 more
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GV-971 Ameliorates Chronic Restraint Stress-Induced Depression-like Phenotypes Accompanied by Reshaping of the Microbiota–Gut–Brain Axis [PDF]

Marine Drugs
Depression is increasingly linked to microbiota–gut–brain axis dysfunction, yet current monoaminergic antidepressants show limited efficacy. This study investigated the therapeutic potential and underlying mechanisms of GV-971, a marine-derived ...
Zhuandi He, Yali Nie, Changcai Li, Guangqiang Sun, Wei Zheng, Hongchun Liu, Meiyu Geng, Jingwei Tian, Yu Zhang   +8 more
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Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction [PDF]

BMC Microbiology
Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear.
Yi Ru, Ying Yu, Chuanxin Liu, Yunge Liu, Dongxia Liu, Ruyan Chen, Xiaowan Chen, Xiaoyang Bai, Tao Jiang, Jiajia Duan   +9 more
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Metabolic signatures and a diagnostic model for citrin deficiency based on urinary organic acids [PDF]

Clinical and Translational Medicine
Purpose This study aimed to characterise urinary organic acid profiles in Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD) and develop a diagnosis model to distinguish NICCD patients from those in the non‐specific metabolic ...
Peiyao Wang, Peichun Chen, Xinjie Yang, Ziyan Cen, Yu Zhang, Qimin He, Benqing Wu, Xinwen Huang   +7 more
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How the gut microbiome affects the immunotherapy response in hepatocellular carcinoma [PDF]

Cancer Biology & Medicine
Hepatocellular carcinoma (HCC) remains a major global health challenge with limited long-term survival despite advances in surgical, locoregional, and systemic treatments.
Mengrui Wu, Yating Zhang, Jun Yu
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“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model

Journal for ImmunoTherapy of Cancer, 2022
Background Amino acid metabolism is essential for tumor cell proliferation and regulation of immune cell function. However, the clinical significance of free amino acids (plasma-free amino acids (PFAAs)) and tryptophan-related metabolites in plasma has ...
Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani   +15 more
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Zwitterionic or Not? Fast and Reliable Structure Determination by Combining Crystal Structure Prediction and Solid-State NMR

Molecules, 2023
When it comes to crystal structure determination, computational approaches such as Crystal Structure Prediction (CSP) have gained more and more attention since they offer some insight on how atoms and molecules are packed in the solid state, starting ...
Federica Bravetti, Raffaele E. Russo, Simone Bordignon, Angelo Gallo, Federica Rossi, Carlo Nervi, Roberto Gobetto, Michele R. Chierotti   +7 more
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8-HQA adjusts the number and diversity of bacteria in the gut microbiome of Spodoptera littoralis

Frontiers in Microbiology, 2023
Quinolinic carboxylic acids are known for their metal ion chelating properties in insects, plants and bacteria. The larval stages of the lepidopteran pest, Spodoptera littoralis, produce 8-hydroxyquinoline-2-carboxylic acid (8-HQA) in high concentrations
Tilottama Mazumdar, Sabine Hänniger, Shantanu P. Shukla, Aishwarya Murali, Stefan Bartram, David G. Heckel, Wilhelm Boland   +6 more
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