Results 31 to 40 of about 7,875 (206)

Quinolinic acid: neurotoxicity [PDF]

The FEBS Journal, 2012
This minireview series reviews some of the most recent findings about quinolinic acid's cellular toxicity and its implications in diseases such as HIV associated neurocognitive disorders, depressive disorders and schizophrenia, and finally therapeutic strategies with drugs able to interfere with quinolinic acid production and/or effects.
openaire   +1 more source

Similarity Between the Action of Pteridines and Tryptophan Metabolites on Lipid Metabolism

Pteridines, 1999
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of anthranilic acid (2.2 and
Rudzite Vera, Jurika Edite, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex [PDF]

, 2005
There is evidence that the kynurenine pathway (KP) and particularly one of its end products, quinolinic acid (QUIN) play a role in the pathogenesis of several major neuroinflammatory diseases, and more particularly AIDS dementia complex (ADC).
Gilles J Guillemin, Lily Wang, Bruce J Brew   +2 more
core   +1 more source

Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]

, 2015
Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL, Havt, A, Leite, Á, Lima, AAM, Lima, NL, Mayneris-Perxachs, J, Moore, SR, Moura, AF, Pinkerton, R, Soares, AM, Swann, JR   +10 more
core   +1 more source

Expression changes of quinolinic acid phosphoribosyltransferase in patients with glioma and its relationship with prognosis

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the expression of quinolinic acid phosphoribosyltransferase (QPRT) in glioma patients and its associations with clinicopathological features and prognosis. Methods Public databases including The Cancer Genome Atlas (TCGA), TARGET,
QIN Hu, ZHENG Yi-tong, LIU Wen, MAIMAITI Aierpati, LI Ya-bin, WANG Yong-xin   +5 more
doaj   +1 more source

Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells

Behavioral Sciences, 2018
Huntington’s disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To
Teresa Serrano Sánchez, María Elena González Fraguela, Lisette Blanco Lezcano, Esteban Alberti Amador, Beatriz Caballero Fernández, María de los Ángeles Robinson Agramonte, Lourdes Lorigados Pedre, Jorge A Bergado Rosado   +7 more
doaj   +1 more source

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]

, 2015
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core   +2 more sources

Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus [PDF]

, 2017
Citation: Gong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi:10.3389/fmicb.2017.
Bikai Zhang, Changchun Tu, Changchun Tu, Huancheng Guo, Jishu Shi, Junjie Jia, Li Zhang, Shijiang Mi, Wenjie Gong, Wenjie Gong, Xiaoming Xie   +10 more
core   +2 more sources

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study [PDF]

, 2017
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer ...
Aagaard, B, Anagnostou, O, Angus, B, Baker, J, Baxter, J, Beigel, J, Beilke, M, Belloso, W, Bennet, R, Bertrand, M, Brekke, K, Brown, S, Campbell, M, Carbonneau, J, Clark, L, Coburn, P, Collaco Moraes, Y, Cooper, D, Courtney-Rogers, D, Davey, RT, Delfino, M, Denning, E, Dewar, R, Dharan, N, DuChene, A, Dwyer, D, Dwyer, DE, Emery, S, Engen, N, Faber, L, Freiberg, M, George, M, Gioukari, V, Glesby, M, Gordin, F, Gover, E, Griffin, TJ, Gunderson, E, Gunter, J, Ham, K, Harrison, M, Herrero, P, Hodgson, SW, Hoover, M, Hudson, F, Jansson, P, Kaewon, P, Kalomenidis, I, Koerbel, G, Kok, J, Kunisaki, KM, La Rosa, A, Lopez, P, Losso, M, Lu, Z, Lundgren, J, Markowitz, N, McConnell, R, Metcalf, J, Moricz, A, Munroe, D, Nahra, R, Natarajan, V, Neaton, JD, Nelson, R, Novak, R, Omotosho, J, Pacciarini, F, Paez, A, Paez-Quinde, M, Parenti, D, Patil, N, Paton, N, Pearson, M, Pett, SL, Polenakovik, H, Portas, B, Quan, SF, Rehman, T, Riska, P, Rizza, S, Robson, R, Ruxrungtham, K, Saenz, MJ, Sanchez, A, Sanchez, RM, Schultz, T, Schwarber, M, Simon, G, Standridge, B, Temesgen, Z, Tillmann, K, Touloumi, G, Ubolyam, S, Uyeki, T, Vjecha, M, Voell, J, Wendt, CH, Wentworth, D, Wolfe, C   +99 more
core   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source