Results 11 to 20 of about 880,028 (202)

Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]

International Journal of Molecular Sciences, 2013
Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova, Franz Hadacek, Vladimir Chobot   +2 more
openaire   +5 more sources

The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases

Gut Microbes, 2021
The interaction disorder between gut microbiota and its host has been documented in different non-communicable diseases (NCDs) such as metabolic syndrome, neurodegenerative disease, and autoimmune disease. The majority of these altered interactions arise
F. Hosseinkhani, A. Heinken, I. Thiele, P. W. Lindenburg, A. C. Harms, T. Hankemeier   +5 more
doaj   +1 more source

The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis

Cells, 2022
Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic features and suicidal behaviors are accompanied by activated immune-inflammatory and oxidative pathways, which may stimulate indoleamine 2,3-dioxygenase (IDO), the ...
Abbas F. Almulla, Yanin Thipakorn, Asara Vasupanrajit, Chavit Tunvirachaisakul, Gregory Oxenkrug, Hussein K. Al-Hakeim, Michael Maes   +6 more
doaj   +1 more source

Methods of preparation and biological activity of quinolinic acid and derivatives [PDF]

, 2003
In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor.
Amarante, Giovanni Wilson, Almeida, Mauro Vieira de, Cardoso, Sílvia Helena, Souza, Marcus Vinícius Nora de, Hyaric, Mireille Le   +4 more
core   +1 more source

Quinolinic acid, the inescapable neurotoxin [PDF]

The FEBS Journal, 2012
Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent during neuroinflammation.
openaire   +2 more sources

Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies [PDF]

, 2014
© Sundaram et al.; licensee BioMed Central. The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS).
Bruce J Brew, Jones, SP, Guillemin, GJ, Gilles J Guillemin, Gayathri Sundaram, Lim, CK, Seray Adams, Chai K Lim, Sundaram, G ; https://orcid.org/, Simon P Jones, Adams, S, Brew, BJ ; https://orcid.org/   +11 more
core   +2 more sources

Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy

Translational Psychiatry, 2022
Depression during and after pregnancy affects up to 20% of pregnant women, but the biological underpinnings remain incompletely understood. As pregnancy progresses, the immune system changes to facilitate fetal development, leading to distinct ...
Qiong Sha, Zach Madaj, Sarah Keaton, Martha L Escobar Galvis, LeAnn Smart, Stanislaw Krzyzanowski, Asgerally T. Fazleabas, Richard Leach, Teodor T. Postolache, Eric D. Achtyes, Lena Brundin   +10 more
doaj   +1 more source