Results 11 to 20 of about 4,572 (161)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Virology Journal, 2023 Background Influenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a highly contagious disease that can be deadly, especially in high-risk groups.
Huda A. M. Al-Shalan +8 more
doaj +1 more source
Effect of Dietary Acrylamide Exposure on Blood Glucose Metabolism and Organ Functions of Type 2 Diabetic GK Rats [PDF]
Shipin Kexue, 2023 Objective: To investigate the effect of dietary acrylamide exposure on the progression of type 2 diabetes in GK rats. Methods: The effects of intragastric administration of acrylamide (2 mg/(kg mb·d)) for eight weeks on blood glucose metabolism ...
XIE Yiting, PENG Fei, LOU Aihua, SHEN Qingwu, CHEN Jie, QUAN Wei
doaj +1 more source
Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine. [PDF]
PLoS ONE, 2016 We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify ...
Anthony Laugeray +6 more
doaj +1 more source
Systemic long-term metabolic effects of acute non-severe paediatric burn injury
Scientific Reports, 2022 A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity.
Sofina Begum +13 more
doaj +1 more source
Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]
International Journal of Molecular Sciences, 2013 Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova +2 more
openaire +5 more sources
Gut Microbes, 2021 The interaction disorder between gut microbiota and its host has been documented in different non-communicable diseases (NCDs) such as metabolic syndrome, neurodegenerative disease, and autoimmune disease. The majority of these altered interactions arise
F. Hosseinkhani +5 more
doaj +1 more source
Cells, 2022 Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic features and suicidal behaviors are accompanied by activated immune-inflammatory and oxidative pathways, which may stimulate indoleamine 2,3-dioxygenase (IDO), the ...
Abbas F. Almulla +6 more
doaj +1 more source
Quinolinic acid, the inescapable neurotoxin [PDF]
The FEBS Journal, 2012 Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent during neuroinflammation.
openaire +2 more sources
Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids
E-Journal of Chemistry, 2012 Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj +1 more source