Results 41 to 50 of about 880,028 (202)

KXS Balances the Tryptophan Metabolism in Mild to Moderate Depressed Patients and Chronic Restraint Stress Induced Depressive Rats

Neuropsychiatric Disease and Treatment, 2022
Yuanbo Wang1,2 *, Xia Li1,2 *, Rui Jing,2 Wenshan Yang,1,2 Yichen Wang,1,2 Chaochen Wang,1,2 Lei Yao,1,2 Xiaoming Cui,3 Yuan Hu2 1Graduate School of PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Pharmacy ...
Wang Y, Li X, Jing R, Yang W, Wang Y, Wang C, Yao L, Cui X, Hu Y   +8 more
doaj  

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

Tryprophan metbolism in alcoholism. Tryptophan but not excitatory amino acid availablity to the brain is increased before the appearance of the alcohol-withdrawal syndrome in men [PDF]

, 1998
Tryptophan (Trp) metabolism and disposition and excitatory and other amino acid concentrations were determined in alcohol-dependent subjects in relation to the alcohol-withdrawal syndrome (AWS).
Morgan, Christopher J., Spies, Claudia D., Badaway, Abdulla A.-B, Blum, Susanne, Ehlert, Annette, Rommelspacher, Hans, Bonner, Adrian B., Bradley, Don M.   +7 more
core  

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Roles for Cationic Residues at the Quinolinic Acid Binding Site of Quinolinate Phosphoribosyltransferase [PDF]

Biochemistry, 2010
Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP). Previously determined crystal structures of QAPRTase.QA and QAPRTase.PA.PRPP complexes show positively charged residues (Arg118, Arg152, Arg175, Lys185, and His188) lining the QA
Zainab, Bello, Charles, Grubmeyer
openaire   +2 more sources

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture

, 2005
Quinolinic acid is a well-known excitotoxin that induces oxidative stress and damage. In the present study, oxidative damage to biomolecules was followed by measuring lipid peroxidation and protein carbonyl formation in rat brain tissue culture over a ...
Tomás-Zapico, Cristina, Álvarez-García, Oscar, Vega-Naredo, Ignacio, Poeggeler, Burkhard, Sierra-Sánchez, Verónica, Rodríguez-Colunga, María J., Caballero, Beatriz, Tolivia, Delio, Coto-Montes, Ana   +8 more
core   +1 more source

Wuwei Jianpi San Improves Growth Performance and Immune Status in Yaks Through Modulation of Rumen Microbiota and Host Metabolism

Animals
To investigate the effects of Wuwei Jianpi San (WJPS), a Chinese herbal compound feed additive, on rumen microecology, host metabolism, and immune function in healthy yaks (Bos grunniens), and to determine the optimal supplementation level, 32 yaks with ...
Ke Zhou, Hongmei Shi, Xiangying Kong, Weidong Ma, Jianguo Kang, Haizhong Che, Yongli Hua   +6 more
doaj   +1 more source

Systemic and central nervous system metabolic alterations in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2019
Background Metabolic alterations, related to cerebral glucose metabolism, brain insulin resistance, and age-induced mitochondrial dysfunction, play an important role in Alzheimer’s disease (AD) on both the systemic and central nervous system level.
Vera van der Velpen, Tony Teav, Héctor Gallart-Ayala, Florence Mehl, Ioana Konz, Christopher Clark, Aikaterini Oikonomidi, Gwendoline Peyratout, Hugues Henry, Mauro Delorenzi, Julijana Ivanisevic, Julius Popp   +11 more
doaj   +1 more source

BMAL1 in Anterior Cingulate Cortex Pyramidal Neurons Relieves Pulpitis‐Induced Nocturnal Pain

International Endodontic Journal, EarlyView.
ABSTRACT Aim Nocturnal exacerbation of pulpitis‐induced pain severely disrupts patients' sleep and quality of life, increasing emergency dental care burden. However, the exact mechanisms underlying nocturnal pain remain poorly understood, limiting the development of targeted analgesic strategies.
Yuting Bai, Jialin Si, Jing Zhang, Zhuo Yu, Meng Nian, Yundi Qiao, Xiaoke Wu, Jing Huang, Li‐an Wu   +8 more
wiley   +1 more source