Results 171 to 180 of about 2,516,709 (214)

Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
openaire   +3 more sources

Brain quinolinic acid in Alzheimer's dementia

European Archives of Psychiatry and Neurological Sciences, 1989
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic, J, Halket, A, Przyborowska, P, Riederer, H, Beckmann, M, Sandler, K, Jellinger   +6 more
openaire   +2 more sources

Quinolinic acid in children with congenital hyperammonemia

Annals of Neurology, 1993
AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw, M B, Robinson, K, Hyland, S, Djali, M P, Heyes   +4 more
openaire   +2 more sources

Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds, S J, Pearson, J, Halket, M, Sandler   +3 more
openaire   +2 more sources

Quinolinic Acid: A Pathogen in Seizure Disorders?

1986
The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz, C, Speciale, E, Okuno, E D, French, C, Köhler   +4 more
openaire   +2 more sources

Bromodecarboxylation of Quinoline Salicylic Acids: Increasing the Diversity of Accessible Substituted Quinolines

The Journal of Organic Chemistry, 2009
Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Kristin, Janz, Neelu, Kaila
openaire   +2 more sources

Quinolinic acid-immunoreactivity in the naïve mouse brain

Journal of Chemical Neuroanatomy, 2016
Quinolinic acid (QUIN) has been suggested to be involved in infections, inflammatory neurological disorders and in the development of psychiatric disorders. In this view, several studies have been performed to investigate QUIN localization in the brain and its neurotoxic effects.
Lopez, Yara Pujol, Kenis, Gunter, Rutten, Bart P. F., Myint, Aye M., Steinbusch, Harry W. M., van den Hove, Daniel L. A.   +5 more
openaire   +3 more sources

QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

2003
We propose that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that after 72 hours amyloid peptide (Abeta) 1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and in a ...
Gilles J, Guillemin, Kieran R, Williams, Danielle G, Smith, George A, Smythe, Juliana, Croitoru-Lamoury, Bruce J, Brew   +5 more
openaire   +2 more sources

Oligodendrocyte killing by quinolinic acid in vitro

Brain Research, 2001
Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
openaire   +2 more sources

Quinolinic Acid and Inflammation

Annals of the New York Academy of Sciences, 1993
openaire   +2 more sources