Results 171 to 180 of about 15,449 (218)

Quinolinic acid: regional variations in neuronal sensitivity

Brain Research, 1983
The excitatory action of quinolinic acid has been examined on neurons in different parts of the rat CNS. When applied by microiontophoresis quinolinic acid excited cells in the cerebral cortex, hippocampus and neostriatum, but even when applied from electrodes which produced responses in these areas, quinolinic acid was ineffective in the cerebellum ...
M N, Perkins, T W, Stone
openaire   +4 more sources

Quinoline-4-carboxylic Acid

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
openaire   +3 more sources

A radioenzymatic assay for quinolinic acid

Analytical Biochemistry, 1986
A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
A C, Foster, E, Okuno, D S, Brougher, R, Schwarcz   +3 more
openaire   +2 more sources

Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
S, Klahr, A C, Schoolwerth
openaire   +2 more sources

Brain quinolinic acid in Alzheimer's dementia

European Archives of Psychiatry and Neurological Sciences, 1989
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
E, Sofic, J, Halket, A, Przyborowska, P, Riederer, H, Beckmann, M, Sandler, K, Jellinger   +6 more
openaire   +2 more sources

Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
G P, Reynolds, S J, Pearson, J, Halket, M, Sandler   +3 more
openaire   +2 more sources

Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid

Biochemical and Biophysical Research Communications, 1988
The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
openaire   +2 more sources

Boric acid catalyzed chemoselective reduction of quinolines

Organic & Biomolecular Chemistry, 2020
Boric acid promoted transfer hydrogenation of substituted quinolines to synthetically versatile 1,2,3,4-tetrahydroquinolines (1,2,3,4-THQs) was described under mild reaction conditions using a Hantzsch ester as a mild organic hydrogen source.
Dipanjan Bhattacharyya, Sekhar Nandi, Priyanka Adhikari, Bikash Kumar Sarmah, Monuranjan Konwar, Animesh Das   +5 more
openaire   +2 more sources

Quinolinic Acid and Kynurenic Acid in the Mammalian Brain

1991
Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
openaire   +2 more sources

Memantine prevents quinolinic acid-induced hippocampal damage

European Journal of Pharmacology, 1992
Memantine, used as a drug for treatment of spasticity and other extrapyramidal disorders as well as dementia, was shown to prevent brain damage caused by the glutamate (N-methyl-D-aspartate, NMDA) receptor agonist, quinolinic acid. Studies were focused on the hippocampal formation which is known to be highly vulnerable to quinolinate.
G, Keilhoff, G, Wolf
openaire   +2 more sources