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Tryptophan-Derived Metabolites and Glutamate Dynamics in Fatal Insulin Poisoning: Mendelian Randomization of Human Cohorts and Experimental Validation in Rat Models. [PDF]
Int J Mol SciYuan Y +7 more
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Biomedical chromotography, 2022
sKynurenine (KYN) is synthesized from an essential amino acid, tryptophan by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase via N-formyl- KYN in vivo. Subsequently, KYN acts as a precursor of some neuroactive metabolites such as kynurenic acid,
T. Fukushima +3 more
semanticscholar +1 more source
sKynurenine (KYN) is synthesized from an essential amino acid, tryptophan by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase via N-formyl- KYN in vivo. Subsequently, KYN acts as a precursor of some neuroactive metabolites such as kynurenic acid,
T. Fukushima +3 more
semanticscholar +1 more source
Quinoline-4-carboxylic Acid [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 1998 The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The dihedral angle between the best-fit quinoline core plane and the carboxyl plane is 45.9 (1) degrees ...
Amonette, Allison J., Gerkin, Roger E.
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A radioenzymatic assay for quinolinic acid
Analytical Biochemistry, 1986A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid ...
Daniel S. Brougher +3 more
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Brain quinolinic acid in Alzheimer's dementia
European Archives of Psychiatry and Neurological Sciences, 1989Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method.
Peter Riederer +6 more
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Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid
Biochemical and Biophysical Research Communications, 1988The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
Linda Kalikin, K.C. Calvo
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The Crystal Structure of Quinolinic Acid
Bulletin of the Chemical Society of Japan, 1973Abstract The crystal structure of quinolinic acid (2,3-pyridinedicarboxylic acid) has been determined by the method of X-ray diffraction. The crystal is monoclinic, with a space group of P21/c and with cell dimensions of a=7.421, b=12.729, c=7.850 Å, and β=116.96°.
Akira Shimada +2 more
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ChemInform Abstract: Bromodecarboxylation of Quinoline Salicylic Acids: Increasing the Diversity of Accessible Substituted Quinolines. [PDF]
ChemInform, 2009 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neelu Kaila, Kristin Janz
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