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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Quinolinic Acid Accumulation During Neuroinflammation
Annals of the New York Academy of Sciences, 2001Abstract:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist ofN‐methyl‐d‐aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation.
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Oligodendrocyte killing by quinolinic acid in vitro
Brain Research, 2001Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
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Quinolinic Acid and Inflammation
Annals of the New York Academy of Sciences, 1993openaire +2 more sources
MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2014Ioana Berindan-Neagoe +2 more
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Advances in Prostate Cancer Chemotherapy: A New Era Begins
Ca-A Cancer Journal for Clinicians, 2005Kenneth J Pienta, David C Smith
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