Results 231 to 240 of about 5,025,784 (284)

ChemInform Abstract: Bromodecarboxylation of Quinoline Salicylic Acids: Increasing the Diversity of Accessible Substituted Quinolines. [PDF]

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neelu Kaila, Kristin Janz
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
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Quinolinic Acid Phosphoribosyltransferase in Rat Brain

Journal of Neurochemistry, 1985
Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
Alan C. Foster, Robert Schwarcz, William C. Zinkand   +2 more
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The quinolinic acid hypothesis in Huntington's chorea

Journal of the Neurological Sciences, 1990
In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R.P.M. Bruyn, J.C. Stoof
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Brain Quinolinic Acid in Huntington's Disease

Journal of Neurochemistry, 1988
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method.
Gavin P. Reynolds, S.J. Pearson, J Halket, M. Sandler   +3 more
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Quinolinic acid in children with congenital hyperammonemia

Annals of Neurology, 1993
AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
Michael B. Robinson, Mark L. Batshaw, Sina Djali, Keith Hyland, Melvyn P. Heyes   +4 more
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A photometric method for the determination of quinolinic acid

Archives of Biochemistry and Biophysics, 1953
Abstract 1. 1. A photometric method is described for the determination of quinolinic acid in trichloroacetic acid extracts of tissue preparations which have metabolized 3-hydroxyanthranilic acid. 2. 2. The method is based on the measurement of the stable yellow color of the ferrous chelate of quinolinic acid.
M. Rabinovitz, R.A. Fineberg, David M. Greenberg   +2 more
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Triflouroacetic Acid as an Efficient Catalyst for the Synthesis of Quinoline [PDF]

Synthetic Communications, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ebrahim Soleimani, Ahmad Shaabani, Zahra Badri   +2 more
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Renal gluconeogenesis effects of quinolinic acid

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract Quinolinic acid, a metabolic degradation product of tryptophan metabolism and a known inhibitor of hepatic gluconeogenesis in vivo, has been shown in the present studies to inhibit renal gluconeogenesis in vitro. At pH 7.4 quinolinic acid decreased glucose production from glutamine and glutamate by rat renal cortex by more than 50%.
Anton C. Schoolwerth, Saulo Klahr
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Neuropharmacology of quinolinic and kynurenic acids.

Pharmacological Reviews, 1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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