Results 241 to 250 of about 5,025,784 (284)

The Neuropharmacology of Quinolinic Acid and the Kynurenines

1986
Quinolinic acid is an endogenous compound with actions on the NMA receptor to produce neuronal excitation, toxicity and convulsions. It does not appear to be taken up by membrane transport processes in the brain, and it may therefore function as a long term modulator of neuronal excitability rather than as a classical neurotransmitter. Alternatively it
P.A. Brooks, Trevor W. Stone, J. I. Addae, D. A. S. Smith, Jonathan H. Connick   +4 more
openaire   +2 more sources

Hydrothermal Decarboxylation of Pentafluorobenzoic Acid and Quinolinic Acid

Industrial & Engineering Chemistry Research, 2009
We report herein the first kinetics studies of hydrothermal decarboxylation of a fully halogenated benzoic acid and a heterocyclic aromatic diacid. Decarboxylation was the only reaction path observed, and there was no evidence of dehalogenation. Experiments at different initial reactant concentrations and different batch holding times revealed that ...
Phillip E. Savage, Xiuyang Lu, Jie Fu
openaire   +2 more sources

Quinolinic Acid and Active Oxygens

1996
Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983).
Y. Hamane, S. Shimizu, Ritsuko Kishimoto, Miwa Ueda, Kiyoshi Goda   +4 more
openaire   +2 more sources

Quinolinic Acid: A Pathogen in Seizure Disorders?

1986
The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
Edward D. French, Christer Köhler, Carmela Speciale, Robert Schwarcz, Etsuo Okuno   +4 more
openaire   +3 more sources

Quinolinic acid-immunoreactivity in the naïve mouse brain

Journal of Chemical Neuroanatomy, 2016
Quinolinic acid (QUIN) has been suggested to be involved in infections, inflammatory neurological disorders and in the development of psychiatric disorders. In this view, several studies have been performed to investigate QUIN localization in the brain and its neurotoxic effects.
Gunter Kenis, Aye Mu Myint, Aye Mu Myint, Yara Pujol Lopez, Harry W.M. Steinbusch, Bart P. F. Rutten, Daniel L.A. van den Hove, Daniel L.A. van den Hove   +7 more
openaire   +4 more sources

QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

2003
We propose that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that after 72 hours amyloid peptide (Abeta) 1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and in a ...
George A. Smythe, Kieran R. Williams, Juliana Croitoru-Lamoury, Danielle G. Smith, Bruce J. Brew, Gilles J. Guillemin   +5 more
openaire   +3 more sources

ChemInform Abstract: REDUCTIONS OF SOME ACIDS OF THE QUINOLINE SERIES

Chemischer Informationsdienst, 1978
AbstractDie Chinolincarbonsäuren (I) werden mit Triethylformiat im Pyridinring reduziert (Bildung der Produkte (II) bzw. (IV) bzw. (V) + (VI); zwecks besserer Isolierung wird (IIc) in (IIIa) (daneben (IIIb)) übergeführt).
Miloslav Ferles, Oldřich Kocián
openaire   +3 more sources

Oligodendrocyte killing by quinolinic acid in vitro

Brain Research, 2001
Quinolinic acid, which is produced by macrophages and microglia, can kill neurons in vivo and in vitro. To test whether quinolinic acid is toxic to oligodendrocytes, glial cells cultured from the brains of 2-day-old rats were incubated with quinolinic acid at concentrations known to kill neurons.
openaire   +3 more sources

Acid-base properties of hydrogenated quinolines

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1984
The pK's of short-lived aminic free radicals from 1,2-dihydro- and 1,2,3,4-tetrahydroquinolines were determined. It was shown that the free radicals are stronger bases than the starting amines.
N. O. Pirogov, N. O. Pirogov, Ya. N. Malkin, Ya. N. Malkin, M. V. Kopytina, M. V. Kopytina, V. I. Nosova, V. I. Nosova   +7 more
openaire   +2 more sources

Effect of quinolinic acid on the distribution of hepatic metabolites

Biochemical and Biophysical Research Communications, 1973
Abstract The intracellular distribution of hepatic metabolites in normal and quinolinic acid (QA)-treated rats has been calculated. QA, an inhibitor of gluconeogenesis, raises the total cell content of malate, aspartate, α-ketoglutarate and citrate.
O.S. Spydevold, O.S. Spydevold, A. L. Greenbaum, A. L. Greenbaum, P. McLean, P. McLean   +5 more
openaire   +3 more sources