Results 11 to 20 of about 136,091 (317)
MedChemComm, 2019 The quinolone antibiotics arose in the early 1960s, with the first examples possessing a narrow-spectrum activity with unfavorable pharmacokinetic properties.
Thu D. M. Pham +2 more
openaire +5 more sources
Quinolone Antibiotics: Resistance and Therapy
Infection and Drug Resistance, 2023 The clinical application of quinolone antibiotics is particularly extensive. In addition to their high efficiency in infectious diseases, the treatment process brings multiple hidden dangers or side effects.
Kai Tang, Heng Zhao
semanticscholar +1 more source
Quinolone: a versatile therapeutic compound class
Molecular diversity, 2022 The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new area of research that has led to the discovery of several life-saving antimicrobial agents (generally referred to as fluoroquinolones) for over decades.
Phelelisiwe S. Dube +2 more
semanticscholar +1 more source
Infection and Drug Resistance, 2021 Background and Aim Recently, the extensive use of quinolones led to increased resistance to these antimicrobial agents, with different rates according to the organism and the geographical region. The aim of this study was to detect the resistance rate of
S. Kareem +11 more
semanticscholar +1 more source
Scientific Reports, 2022 This study aimed to assess the presence of qnrA, qnrB, qnrC, qnrD, qnrS, qepA, and aac(6′)-Ib-cr determinants as well as quinolone resistance pattern of clinical isolates of P. aeruginosa in Ahvaz, southwest Iran.
M. Saki +8 more
semanticscholar +1 more source
Antibiotics, 2021 Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and
A. Shaheen +6 more
semanticscholar +1 more source
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
core +3 more sources
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
core +1 more source
Primer relevamiento de marcadores de resistencia a antibióticos en Enterobacteriaceae en Cochabamba, Bolivia [PDF]
, 2017 Se llevó a cabo un relevamiento molecular de la resistencia a antibióticos de importancia clínica en aislamientos recuperados en Cochabamba, Bolivia. Se estudiaron los genes codificantes de β-lactamasas de espectro extendido y de resistencia a quinolonas
Di Conza, José Alejandro +3 more
core +1 more source
Genomic Characterization of Salmonella Isangi: A Global Perspective of a Rare Serovar
Antibiotics, 2023 Salmonella Isangi is an infrequent serovar that has recently been reported in several countries due to nosocomial infections. A considerable number of reports indicate Salmonella Isangi multidrug resistance, especially to cephalosporins, which could ...
Anamaria Mota Pereira dos Santos +7 more
doaj +1 more source