Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases [PDF]
, 2007 Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase ...
GIARETTA G +15 more
core +1 more source
Total Synthesis and Antimalarial Studies of Caelestines A-C. [PDF]
ChemMedChemTotal synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Smith HST, Lock AM, Avery VM, Davis RA.
europepmc +2 more sources
Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance
Frontiers in Microbiology, 2023 Quinolone resistance presents a growing global health threat. We employed word-based GWAS to explore genomic data, aiming to enhance our understanding of this phenomenon.
Negin Malekian +5 more
doaj +1 more source
, 2022 Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective ...
Xu Lian (8321775) +11 more
core +1 more source
Crystal structure of ethyl 8-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C12H10ClNO3, the asymmetric unit comprises two independent molecules, and the dihedral angle between the least-square planes of the quinoline ring systems of these molecules is 73.30 (5)°.
Yoshinobu Ishikawa, Nanako Yoshida
doaj +1 more source
Quinolone and Organophosphorus Insecticide Residues in Bivalves and Their Associated Risks in Taiwan
Molecules, 2020 Bivalves, such as freshwater clams (Corbicula fluminea) and hard clams (Meretrix lusoria), are the most extensive and widely grown shellfish in land-based ponds in Taiwan.
Ching-Feng Wu +10 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2004 The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity.
Carmen E Contreras +6 more
doaj +1 more source
Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium
Microbiology Spectrum, 2022 Here, we performed in vitro susceptibility testing on 10 Mycoplasma genitalium isolates against omadacycline, minocycline, tetracycline, doxycycline, moxifloxacin, levofloxacin, and azithromycin.
Ken B. Waites +4 more
doaj +1 more source
"One Pot" Synthesis of 1,5-Diaza-2,3,6,7-Thetrahydro-4-Methyl-Phenanthrene-4,8-Dione From Corresponding Bis-Beta-Amino Acid [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1999 The cyclization of b-anilino propionic acids in the presence of polyphosphoric acid (PPA) afforded the 2,3-Dihydroquinoline-4-(1H)-ones in good yields. N,N'-bis(2-carboxyethyl)-4-methyl-1,2-diaminobenzene (7) is cyclized under this condition to produce ...
Abbas Shokravi +1 more
doaj
In vitro Antibacterial Activity of Vitamin C and in Combination with Ciprofloxacin against Uropathogenic Escherichia coli [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Multidrug Resistant (MDR) bacteria have become a major cause for concern; there has been limited success in the search for newer antibiotics. The search for options has led researchers to vitamin C, an unlikely ally.
Rohan Jacob Verghese +2 more
doaj +1 more source