Results 31 to 40 of about 71,327 (249)

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]

, 2006
Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM, RICHTER, SARA, Giaretta, G, LEO, ELISABETTA, GIARETTA, GIULIA, Palumbo, M, Leo, E, FISHER L. M, Richter, SN, Gatto, B, GATTO, BARBARA, PALUMBO, MANLIO   +11 more
core   +1 more source

Development of the quinolones [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and scientific interest. Nalidixic acid, the first quinolone to be developed, was obtained as an impurity during the manufacture of quinine.
Monique I, Andersson, Alasdair P, MacGowan   +1 more
openaire   +2 more sources

A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles [PDF]

The Journal of Organic Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Daniel, Zewge, Cheng-Yi, Chen, Curtis, Deer, Peter G, Dormer, Dave L, Hughes   +4 more
openaire   +2 more sources

Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant staphylococcus aureus

, 2014
Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA).
Xiaobei Pan, S. W. Annie Bligh, Eileen Smith, Pan, X., Bligh, S.W.A., Smith, E.   +5 more
core   +1 more source

Inhibiting quinolone biosynthesis of Burkholderia

, 2021
2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first ...
Filz, Verena, Prothiwa, Michaela, Oehler, Sebastian, Böttcher, Thomas   +3 more
core   +1 more source

Crystal structure of 2-chloro-3-(dimethoxymethyl)-6-methoxyquinoline

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C13H14ClNO3, crystallizes with Z′ = 2 in the space group Pca21, but a search for possible additional crystallographic symmetry found none.
Nanjappa Chandrika, Tholappanavara H. Suresha Kumara, Jerry P. Jasinski, Sean P. Millikan, Hemmige S. Yathirajan, Christopher Glidewell   +5 more
doaj   +1 more source

Antibacterial Residue Excretion via Urine as an Indicator for Therapeutical Treatment Choice and Farm Waste Treatment

Antibiotics, 2021
Many of the infectious diseases that affect livestock have bacteria as etiological agents. Thus, therapy is based on antimicrobials that leave the animal’s tissues mainly via urine, reaching the environment through slurry and waste water.
María Jesús Serrano, Diego García-Gonzalo, Eunate Abilleira, Janire Elorduy, Olga Mitjana, María Victoria Falceto, Alicia Laborda, Cristina Bonastre, Luis Mata, Santiago Condón, Rafael Pagán   +10 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Imidoylketene−Oxoketenimine Interconversion. Rearrangement of a Carbomethoxyketenimine to a Methoxyimidoylketene and 2-Methoxy-4-quinolone

, 2016
FVP of triazole 13 produces the isolable ketenimine 11 together with indole 15. 11 undergoes reversible interconversion with imidoylketene 10 above 380 °C. The latter cyclizes to quinolone 12.
Curt Wentrup (1433587), Belinda E. Fulloon (3036453)   +1 more
core   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source