Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
core +1 more source
Approaching zero : temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus [PDF]
, 2013 A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign.
Christison, F. +5 more
core +3 more sources
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment [PDF]
, 2009 The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is crucial for the institution of appropriate treatment regimens as early as possible.
Feuerriegel, S +6 more
core +2 more sources
Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
, 2017 Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio +8 more
core +2 more sources
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe [PDF]
, 2012 Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery1,2, spreading efficiently via low-dose fecal-oral transmission3,4. Historically, S.
A Mutreja +55 more
core +4 more sources
Crystal structure of 2-chloro-3-(dimethoxymethyl)-6-methoxyquinoline
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C13H14ClNO3, crystallizes with Z′ = 2 in the space group Pca21, but a search for possible additional crystallographic symmetry found none.
Nanjappa Chandrika +5 more
doaj +1 more source
Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]
, 2013 Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown +27 more
core +2 more sources
Antibiotics, 2021 Many of the infectious diseases that affect livestock have bacteria as etiological agents. Thus, therapy is based on antimicrobials that leave the animal’s tissues mainly via urine, reaching the environment through slurry and waste water.
María Jesús Serrano +10 more
doaj +1 more source
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
core +1 more source
Advanced Science, EarlyView.This study systematically compares the degradation efficiency of CIP in a H2O2‐alone system and a novel Bi12FeO20‐H2O2 photo‐Fenton system. It reveals for the first time the presence of a quinone‐imine intermediate in the H2O2‐alone system, which exhibits toxicity comparable to CIP.
Wenting Qiu +9 more
wiley +1 more source