Results 51 to 60 of about 12,665 (110)

Mining Public Mass Spectrometry Data to Characterize the Diversity and Ubiquity of P. aeruginosa Specialized Metabolites

Metabolites, 2020
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that causes chronic infections of burn wounds and in the lungs of cystic fibrosis (CF) patients.
Andrew C. Lybbert, Justin L. Williams, Ruma Raghuvanshi, A. Daniel Jones, Robert A. Quinn   +4 more
doaj   +1 more source

Quinolone antibiotics

, 2019
The quinolone antibiotics arose in the early 1960s, with the first examples possessing a narrow-spectrum of activity with unfavorable pharmacokinetic properties.
Blaskovich, Mark A. T., Pham, Thu D. M., Ziora, Zyta M.   +2 more
core   +1 more source

Clinical Importance and Epidemiology of Quinolone Resistance [PDF]

, 2014
The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has emerged and increased globally ...
Kim, Eu Suk, Hooper, David, David C. Hooper, Eu Suk Kim   +3 more
core   +1 more source

Complexation of norfloxacin with DNA in the presence of caffeine [PDF]

, 2006
1H NMR spectroscopy (500 MHz) has been used to quantify the complexation of the antibacterial antibiotic Norfloxacin (NOR) with DNA in the presence of Caffeine (CAF). Separate studies have been made for the self-association of NOR, its hetero-association
Davies, David B., Rybakova, K.A., Evstigneev, M.P.   +2 more
core   +1 more source

Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies

Molecules, 2020
“Drug repositioning” is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to current ...
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Marinela Bostan, Valentina Uivarosi   +8 more
doaj   +1 more source

Quinolone Analogue Inhibits Tubulin Polymerization and Induces Apoptosis Via Cdk1-Involved Signaling Pathways

, 2008
Cancer chemotherapeutic agents that interfere with tubulin/ microtubule function are in extensive use. Quinolone is a common structure in alkaloids and its related components exhibit several pharmacological activities.
陳依呈;潘秀玲;鄧哲明;郭盛助;林宗平;何藴芳;黃煜珺;顧記華, CHEN, YING-CHENG;PAN, SHIOW-LIN;TENG, CHE-MING;KUO, SHENG-CHU;LIN, TSUNG-PING;HO, YUNN-FANG;HUANG, YU-CHUN;GUH, JIH-HWA   +1 more
core  

Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae [PDF]

, 2001
BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones.
Cottagnoud, M, Entenza, JM, Taüber, MG, Moreillon, P, Cottagnoud, P, Que, YA   +5 more
core   +2 more sources

2002–2022 Quinolone Resistance in Escherichia coli of Swine in Mainland China: A Meta-Analysis

Veterinary Sciences
Swine have emerged as significant reservoirs of antibiotic-resistant strains and genes. To establish a sound rationale for applying quinolone antibiotics in the swine industry, a meta-analysis was performed on the resistance rate of swine-derived ...
Xuelin Long, Shujun Liu, Runmin Kang, Yue Sun, Mingyue Tian, Lijun Zhao, Changwei Lei, Hongning Wang, Xin Yang   +8 more
doaj   +1 more source

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

Beilstein Journal of Organic Chemistry, 2018
Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones.
Dandan Li, Naoya Oku, Atsumi Hasada, Masafumi Shimizu, Yasuhiro Igarashi   +4 more
doaj   +1 more source

Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis [PDF]

, 2002
In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Delta log(10) cfu/mL x h, similar to the ...
Cottagnoud, M, Täuber, MG, Acosta, F, Cottagnoud, P   +3 more
core   +2 more sources