Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it [PDF]
, 2005 Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone.
Altman +50 more
core +2 more sources
Crystal structure of 2-chloro-3-(dimethoxymethyl)-6-methoxyquinoline
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C13H14ClNO3, crystallizes with Z′ = 2 in the space group Pca21, but a search for possible additional crystallographic symmetry found none.
Nanjappa Chandrika +5 more
doaj +1 more source
Primer relevamiento de marcadores de resistencia a antibióticos en Enterobacteriaceae en Cochabamba, Bolivia [PDF]
, 2017 Se llevó a cabo un relevamiento molecular de la resistencia a antibióticos de importancia clínica en aislamientos recuperados en Cochabamba, Bolivia. Se estudiaron los genes codificantes de β-lactamasas de espectro extendido y de resistencia a quinolonas
Di Conza, José Alejandro +3 more
core +1 more source
The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore
Frontiers in Cellular and Infection Microbiology, 2018 The Pseudomonas quinolone signal (PQS) has been studied primarily in the context of its role as a quorum-sensing signaling molecule. Recent data suggest, however, that this molecule may also function to mediate iron acquisition, cytotoxicity, outer ...
Jinshui Lin +3 more
semanticscholar +1 more source
Inactivation of Quinolone by Feces [PDF]
Journal of Infectious Diseases, 1986 J. J. M. van Saene +2 more
openalex +5 more sources
Frontiers in Microbiology, 2012 Southeast Asia has become the center of rapid industrial development and economic growth. However, this growth has far outpaced investment in public infrastructure, leading to the unregulated release of many pollutants, including wastewater-related ...
Satoru eSuzuki, Phan Thi Phuong eHoa
doaj +1 more source
Synthesis and molecular docking studies of some novel Schiff bases incorporating 6-butylquinolinedione moiety as potential topoisomerase IIβ inhibitors [PDF]
Royal Society Open Science, 2018 A series of novel pyranoquinolinone-based Schiff's bases were designed and synthesized. They were evaluated for topoisomerase IIβ (TOP2B) inhibitory activity, and cytotoxicity against breast cancer cell line (MCF-7) for the development of novel ...
Hany M. Hassanin +3 more
doaj +1 more source
Medical Journal of Babylon, 2023 Background: Staphylococcus aureus is considered an essential etiological factor in several human infections. Although fluoroquinolones are typically used to treat these illnesses, a growing average level of resistance to these medications has been found ...
Emad Noman Hassan Hamza +1 more
doaj +1 more source
A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase [PDF]
, 2009 Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and ...
A. Maxwell +29 more
core +1 more source
Molecules, 2003 The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex
Longguan Zhu +3 more
doaj +1 more source