Results 61 to 70 of about 136,091 (317)

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it [PDF]

, 2005
Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone.
Altman, Br  nger, C. Richert, Chen, Costenaro, Dao-Thi, Dogan, Drlica, Fan, Feigon, G  mez-Pinto, Heddle, Heddle, Ho, Humphrey, Jacobs, K. Siegmund, Kleywegt, Kottysch, Kryatova, Liu, Llorente, M. Printz, M. Riedrich, Mitscher, Mokhir, Morais Cabral, Narayanan, Noble, Noble, Patel, Piotto, Roca, S. Maheshwary, S. Narayanan, Sandstr  m, SantaLucia, Sarracino, Scheek, Shen, Shen, Shen, Shen, Stein, Sugino, Tsai, Tuma, Tuma, W. Connors, Wigley, Yan   +50 more
core   +2 more sources

Magnetic Pinecone Biochar‐Activated Peroxymonosulfate for Efficient Sulfamethoxazole Degradation: Performance, Mechanism, and Toxicity Analysis

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study successfully prepared magnetic iron/cobalt codoped biochar catalyst (CFSBC) using a one‐step calcination method. The morphology and structure of the material were systematically characterized using SEM, XRD, FTIR, TEM, BET, Raman, VSM, and XPS techniques. The effects of key parameters such as catalyst dosage, peroxymonosulfate (PMS)
Jianhua Ni, Haoyuan Zheng, Guishang Sheng, Xi Zhang   +3 more
wiley   +1 more source

Could traces of fluoroquinolones in food induce ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae? An in vivo study in Galleria mellonella with important implications for maximum residue limits in food

Microbiology Spectrum
We hypothesized that the residual concentrations of fluoroquinolones allowed in food (acceptable daily intake—ADIs) could select for ciprofloxacin resistance in our resident microbiota.
Zina Gestels, Yuliia Baranchyk, Dorien Van den Bossche, Jolein Laumen, Said Abdellati, Basil Britto Xavier, Sheeba Santhini Manoharan-Basil, Chris Kenyon   +7 more
doaj   +1 more source

Penicillin allergy de‐labelling in the critical care unit: Simulations to design an intravenous drug provocation test that mirrors the plasma profile of an enteral challenge

British Journal of Clinical Pharmacology, EarlyView.
The majority of penicillin allergy labels are incorrect and a label of penicillin allergy is associated with worse outcomes and increased use of healthcare services. Penicillin allergy assessment and de‐labelling may be considered in critically ill patients. An oral penicillin challenge is a common component of most penicillin allergy protocols.
Cleodie Swire, Sean Keane, Reya Vinay Shah, Toqa El‐Nahhas, Iao Lei, Salma Alamin, Niall Conlon, Dagan Osborne Lonsdale   +7 more
wiley   +1 more source

Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone

Molecules, 2003
The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex
Longguan Zhu, Xuchun Fu, Guoping Wang, Guangguo Wu   +3 more
doaj   +1 more source

Quantitative Risk Assessment of Susceptible and Ciprofloxacin-Resistant Salmonella from Retail Pork in Chiang Mai Province in Northern Thailand

Foods, 2022
The adverse human health effects as a result of antimicrobial resistance have been recognized worldwide. Salmonella is a leading cause of foodborne illnesses while antimicrobial resistant (AMR) Salmonella has been isolated from foods of animal origin ...
Chaiwat Pulsrikarn, Anusak Kedsin, Parichart Boueroy, Peechanika Chopjitt, Rujirat Hatrongjit, Piyarat Chansiripornchai, Nipattra Suanpairintr, Suphachai Nuanualsuwan   +7 more
doaj   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]

, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo, Afonine, Amundsen, Amundsen, Bannister, Baños-Sanz, Cano, Cirz, CLSI, Cole, Court, Court, Cronan, Darrigo, Datta, Dillingham, Emsley, Forage, González-Soltero, Henderson, Kennaway, Kulkarni, Li, Liu, Liu, López, McDaniel, Murphy, Murphy, Murphy, Muyrers, Paczosa, Pettersen, Robinson, Sakaki, Scheres, Singleton, Tamae, Urnavicius, Wang, Wiegand, Wigley, Wilkinson, Zhang, Zhang   +44 more
core   +5 more sources

Investigation of six plasmid-mediated quinolone resistance genes among clinical isolates of pseudomonas: a genotypic study in Saudi Arabia

Infection and Drug Resistance, 2019
Background: Quinolones are among the most effective antibiotics against Pseudomonas spp. Several chromosomal and/or plasmid-mediated quinolone-resistance mechanisms have been found in Pseudomonas.
Mohamed F El-Badawy, Majed Alrobaian, M. Shohayeb, S. Abdelwahab   +3 more
semanticscholar   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source