Results 71 to 80 of about 103,486 (339)

Enantiopure Chiral Crystals: A Powerful Tool for Absolute Asymmetric Synthesis

Asian Journal of Organic Chemistry, EarlyView.
This review covers absolute asymmetric syntheses, which allow the preparation of enantiomerically enriched chiral compounds from achiral precursors. By exploiting the crystallization of certain compounds as a conglomerate, enantiopure chiral crystals are spontaneously obtained.
Jiacheng Li, Valérie Alezra
wiley   +1 more source

Stage-specific activity of potential antimalarial compounds measured in vitro by flow cytometry in comparison to optical microscopy and hypoxanthine uptake

Memorias do Instituto Oswaldo Cruz, 2004
The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity.
Carmen E Contreras, María A Rivas, José Domínguez, Jaime Charris, Mario Palacios, Nicolás E Bianco, Isaac Blanca   +6 more
doaj   +1 more source

Lanthanum triflate triggered synthesis of tetrahydroquinazolinone derivatives of N-allyl quinolone and their biological assessment [PDF]

Journal of the Serbian Chemical Society, 2012
A series of 24 derivatives of tetrahydroquinazolinone has been synthesized by one-pot cyclocondensation reaction of N-allyl quinolones, cyclic β-diketones and (thio)urea/N-phenylthiourea in presence of lanthanum triflate catalyst.
Jardosh Hardik H., Patel Manish P.
doaj   +1 more source

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Fisher, LM, Laponogov, I, Pan, XS, Sanderson, MR, Sohi, MK, Veselkov, DA   +5 more
core   +3 more sources

Quinolones in 2005: an update [PDF]

Clinical Microbiology and Infection, 2005
Quinolones are one of the largest classes of antimicrobial agents used worldwide. This review considers the quinolones that are available currently and used widely in Europe (norfoxacin, ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin) within their historical perspective, while trying to position them in the context of recent and possible ...
Van Bambeke, Françoise, Michot, Jean-Michel, Van Eldere, Johan, Tulkens, Paul M.   +3 more
openaire   +3 more sources

Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes among Klebsiella pneumoniae Clinical Isolates Recovered from Egyptian Patients

International Journal of Microbiology, 2017
Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrug-resistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and ...
Mohamed F El-Badawy, W. M. Tawakol, Shaymaa W. El-Far, I. Maghrabi, S. Al-ghamdi, M. Mansy, M. Ashour, M. Shohayeb   +7 more
semanticscholar   +1 more source

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Molecules, 2022
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and Q8a–h), in connection with our research interest in developing novel isatin-bearing anti-tubercular candidates.
Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna, Mohamed A. Said   +6 more
doaj   +1 more source

Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica [PDF]

, 2018
Surveillance of antimicrobial resistance (AMR) in non-typhoidal Salmonella enterica (NTS), is essential for monitoring transmission of resistance from the food chain to humans, and for establishing effective treatment protocols.
Achtman, Adesiji, Ao, Ashton, Ashton, Benacer, Boulund, Boyd, Burke, Day, Day, Doumith, Ellington, Feasey, Garcia-Fernandez, Garcia-Migura, Heider, Hopkins, Hopkins, Jones, Kingsley, Langmead, Langridge, Le Hello, Lee, Magnet, Majowicz, Mataseje, McDermott, Nair, Parry, Rahman, Ruiz, Sadouki, Sood, Stoesser, Su, Tam, Tassios, Threlfall, Threlfall, Tyson, Tyson, Villa, Villa, Vo, Wain, Yoshida, Zankari   +48 more
core   +4 more sources

Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal Salmonella isolates from humans and animals in central Ethiopia

Antimicrobial Resistance and Infection Control, 2017
Beta-lactam and quinolone antimicrobials are commonly used for treatment of infections caused by non-typhoidal Salmonella (NTS) and other pathogens. Resistance to these classes of antimicrobials has increased significantly in the recent years.
T. Eguale, J. Birungi, D. Asrat, M. Njahira, J. Njuguna, W. Gebreyes, J. Gunn, A. Djikeng, E. Engidawork   +8 more
semanticscholar   +1 more source

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, EarlyView.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source