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The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers
Current Drug Metabolism, 2002Quinones are ubiquitous in nature and constitute an important class of naturally occurring compounds found in plants, fungi and bacteria. Human exposure to quinones therefore occurs via the diet, but also clinically or via airborne pollutants. For example, the quinones of polycyclic aromatic hydrocarbons are prevalent as environmental contaminants and ...
Terrence J, Monks, Douglas C, Jones
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1974
Abstract Two unusual menaquinones have been revealed during examination of Brevibacterium thiogenitalis and Brevibacterium vitarumen. Both microorganisms were found to contain menaquinones-8 (II-H2) and -9 (II-H2). The major quinone of the former was menaquinone-9 (II-H2) while that of the latter was menaquinone-8 (II-H2).
T, Kanzaki +4 more
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Abstract Two unusual menaquinones have been revealed during examination of Brevibacterium thiogenitalis and Brevibacterium vitarumen. Both microorganisms were found to contain menaquinones-8 (II-H2) and -9 (II-H2). The major quinone of the former was menaquinone-9 (II-H2) while that of the latter was menaquinone-8 (II-H2).
T, Kanzaki +4 more
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Mini-Reviews in Medicinal Chemistry, 2005
Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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Pharmaceutisch Weekblad Scientific Edition, 1991
The therapeutic application of quinones in areas other than oncology, such as in chronic inflammation, has been proposed. However, because of the adverse side-effects on the function and vitality of almost all investigated cell types the therapeutical margin is small.
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The therapeutic application of quinones in areas other than oncology, such as in chronic inflammation, has been proposed. However, because of the adverse side-effects on the function and vitality of almost all investigated cell types the therapeutical margin is small.
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Photochemical additions of aldehydes to quinones, quinone imines and quinone oximes
1968Klinger [1,2] found that 9,10-phenanthrenequinone reacted with aliphatic and aromatic saturated and unsaturated aldehydes e.g. acetaldehyde, benzaldehyde, and cinnamaldehyde under the influence of light. The photo-adducts 1 may be cleaved hydrolytically to give 9,10-phenanthrenediol and RCOOH; it is possible thus to convert aldehydes to the ...
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2004
Quinones are redox molecules widely present in nature. Coenzyme Q is a subsituted benzoquinone having a polyprenyl chain in the 6-position (decaprenyl- in humans). It is a hydrophobic molecule imbedded in the lipid bilayer of mitochondria and other membranes; in mitochondria it is a component of the electron transfer chain and of the oxidative ...
LENAZ, GIORGIO, GENOVA, MARIA LUISA
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Quinones are redox molecules widely present in nature. Coenzyme Q is a subsituted benzoquinone having a polyprenyl chain in the 6-position (decaprenyl- in humans). It is a hydrophobic molecule imbedded in the lipid bilayer of mitochondria and other membranes; in mitochondria it is a component of the electron transfer chain and of the oxidative ...
LENAZ, GIORGIO, GENOVA, MARIA LUISA
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Structure−Activity Study on the Quinone/Quinone Methide Chemistry of Flavonoids
Chemical Research in Toxicology, 2001A structure-activity study on the quinone/quinone methide chemistry of a series of 3',4'-dihydroxyflavonoids was performed. Using the glutathione trapping method followed by HPLC, (1)H NMR, MALDI-TOF, and LC/MS analysis to identify the glutathionyl adducts, the chemical behavior of the quinones/quinone methides of the different flavonoids could be ...
Awad, H.M. +5 more
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The Cofactor Pyrroloquinoline Quinone
Annual Review of Nutrition, 1990Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
J A, Duine +2 more
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